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Meta-Analysis
. 2024 Feb 5;13(1):54.
doi: 10.1186/s13643-023-02426-8.

Comparison of fish oil supplements and corn oil effects on serum lipid profile: a systematic review and meta-analysis of randomized controlled trials

Payam Safaei  1 , Ghazal Bayat  2 , Afsaneh Mohajer  3
Affiliations
Meta-Analysis

Comparison of fish oil supplements and corn oil effects on serum lipid profile: a systematic review and meta-analysis of randomized controlled trials

Payam Safaei et al. Syst Rev. .

Abstract

Background: The present study aimed to investigate the effects of fish oil supplements compared to corn oil on serum lipid profiles by performing a meta-analysis of randomized controlled trials (RCTs).

Methods: Online databases including PubMed, Web of Science, and Scopus were searched until 30 December 2022. Pooled effect sizes were reported as the weighted mean difference (WMD) with 95% confidence intervals (CI). The Cochrane Collaboration's risk-of-bias tool was utilized to evaluate the quality of the studies. Lipid parameters, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL), were assessed in the meta-analysis.

Results: Overall, 16 eligible trials were included in this systematic review and meta-analysis. The results revealed that the fish oil supplements significantly reduced TG (WMD: - 25.50 mg/dl, 95% CI: - 42.44, - 8.57, P = 0.000) levels compared to corn oil. Also, in this study, fish oil supplements had a positive and significant effect on HDL (WMD: 2.54 mg/dl, 95% CI: 0.55, 4.52). There were no significant changes in TC and LDL.

Conclusions: Our findings showed the effects of fish oil supplements on reducing TG and increasing HDL-c compared to corn oil. Further larger and well-designed RCTs are required to confirm these data.

Keywords: Corn oil; Fish oil; HDL; LDL; TC; TG.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of the study selection process
Fig. 2
Fig. 2
Cochrane risk-of-bias assessment
Fig. 3
Fig. 3
Forest plot of clinical trials investigating the comparison of fish oil supplements and corn oil effects on the serum TC
Fig. 4
Fig. 4
Forest plot of clinical trials investigating the comparison of fish oil supplements and corn oil effects on the serum TG
Fig. 5
Fig. 5
Forest plot of clinical trials investigating the comparison of fish oil supplements and corn oil effects on the serum HDL-c
Fig. 6
Fig. 6
Forest plot of clinical trials investigating the comparison of fish oil supplements and corn oil effects on the serum LDL-c
See this image and copyright information in PMC

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