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. 2024 Jan 22:14:1305386.
doi: 10.3389/fendo.2023.1305386. eCollection 2023.

Correlation between systemic inflammatory response index and thyroid function: 2009-2012 NHANES results

Yuze Zhai  1 , Benjun Wang  2 , Weiwei Han  2 , Bianfang Yu  2 , Jichen Ci  3 , Fan An  1
Affiliations

Correlation between systemic inflammatory response index and thyroid function: 2009-2012 NHANES results

Yuze Zhai et al. Front Endocrinol (Lausanne). .

Abstract

Aims: This study investigates the relationship between the Systemic Inflammatory Response Index (SIRI) and thyroid function.

Methods: Utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2009-2012, we excluded participants lacking SIRI or thyroid function data, those under 20 years, and pregnant individuals. SIRI was determined using blood samples. We conducted weighted multivariate regression and subgroup analyses to discern the independent relationship between SIRI and thyroid function.

Results: The study included 1,641 subjects, with an average age of 47.26±16.77 years, including 48.65% males and 51.35% females. The population was divided into three SIRI-based groups (Q1-Q3). Q3, compared to Q1, exhibited higher age-at-onset, greater male prevalence, and increased levels of FT3, FT4, TT4, leukocytes, and triglycerides. This group also showed a higher incidence of diabetes, hypertension, and smoking. Notably, Q1 had lower LDL and HDL levels. SIRI maintained a positive association with FT4 (β = 0.01, 95% CI = 0.00-0.03, P for trend = 0.0071), TT4 (β = 0.20, 95% CI = 0.10, 0.31, P for trend=0.0001), and TPOAb (β = 8.0, 95% CI = 1.77-14.30, P for trend = 0.0120), indicating that each quartile increase in SIRI corresponded to a 0.01 ng/dL increase in FT4, a 0.2 g/dL increase in TT4, and an 8.03 IU/mL rise in TPOAb. The subgroup analysis suggested the SIRI-thyroid function correlation was influenced by hypertension.

Conclusion: Inflammation may impact the development and progression of thyroid function disorders. Proactive anti-inflammatory treatment might mitigate thyroid abnormalities.

Keywords: national health and nutrition examination survey; positive correlation; systemic inflammatory response index; thyroid function; thyroid hormone.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Selection process for the study sample based on the 2009-2012 National Health and Nutrition Examination Survey (NHANES).
Figure 2
Figure 2
Relationship between SIRI and thyroid function. (A–F) is a curve-fit plot of SIRI versus thyroid function (FT3, FT4, TPOAb, TSH, TT3, and TT4). (G–I) is a restricted cubic spline plot of SIRI versus FT3, TT3, and TT4.
Figure 3
Figure 3
Subgroup analysis of SIRI and thyroid function.
See this image and copyright information in PMC

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