Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan;1(1):EVIDstat2100040.
doi: 10.1056/EVIDstat2100040. Epub 2022 Jan 10.

Is Noninferior Not Inferior?

Siri Kadire  1 , Charles C Hardin  2 , Katherine S Takvorian  2 , Chana A Sacks  2
Affiliations

Is Noninferior Not Inferior?

Siri Kadire et al. NEJM Evid. 2022 Jan.

Abstract

Is Noninferior Not Inferior? What is a non-inferiority trial margin? To answer this, ask whether you have ever weighed a tradeoff between the best version of something and an acceptable alternative. Restated, in a choice between two decisions, is one option not inferior to the other? Watch an animated video that explores the basis for non-inferiority trials, the meaning of non-inferiority margins, and the interpretation of a non-inferiority trial's results.

PubMed Disclaimer

Publication types

LinkOut - more resources