Immune Modulation in Sepsis, ARDS, and Covid-19 - The Road Traveled and the Road Ahead

Aleksandra Leligdowicz^{1

2}, Michael O Harhay^{3

4

5}, Carolyn S Calfee^{6

7}

Affiliations

¹ Department of Medicine, Division of Critical Care Medicine, Western University, London, ON, Canada.
² Robarts Research Institute, Western University, London, ON, Canada.
³ Clinical Trials Methods and Outcomes Lab, Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁴ Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁵ Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁶ Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco.
⁷ Cardiovascular Research Institute, University of California, San Francisco, San Francisco.

PMID: 38319856
DOI: 10.1056/EVIDra2200118

Review

Immune Modulation in Sepsis, ARDS, and Covid-19 - The Road Traveled and the Road Ahead

Aleksandra Leligdowicz et al. NEJM Evid. 2022 Nov.

. 2022 Nov;1(11):EVIDra2200118.

doi: 10.1056/EVIDra2200118. Epub 2022 Oct 25.

Authors

Aleksandra Leligdowicz^{1

2}, Michael O Harhay^{3

4

5}, Carolyn S Calfee^{6

7}

Affiliations

¹ Department of Medicine, Division of Critical Care Medicine, Western University, London, ON, Canada.
² Robarts Research Institute, Western University, London, ON, Canada.
³ Clinical Trials Methods and Outcomes Lab, Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁴ Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁵ Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia.
⁶ Department of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco.
⁷ Cardiovascular Research Institute, University of California, San Francisco, San Francisco.

PMID: 38319856
DOI: 10.1056/EVIDra2200118

Abstract

Immune Modulation in Sepsis, ARDS, and Covid-19Leligdowicz et al. consider the history and future of immunomodulating therapies in sepsis and ARDS, including ARDS due to Covid-19, and remark on the larger challenge of clinical research on therapies for syndromes with profound clinical and biologic heterogeneity.

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Immune Modulation in Sepsis, ARDS, and Covid-19 - The Road Traveled and the Road Ahead

Affiliations

Immune Modulation in Sepsis, ARDS, and Covid-19 - The Road Traveled and the Road Ahead

Authors

Affiliations

Abstract

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical