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Review
. 2023 Dec;2(12):EVIDra2300160.
doi: 10.1056/EVIDra2300160. Epub 2023 Nov 28.

Methamphetamine Toxicities and Clinical Management

Phillip O Coffin  1   2 , Leslie W Suen  2
Affiliations
Review

Methamphetamine Toxicities and Clinical Management

Phillip O Coffin et al. NEJM Evid. 2023 Dec.

Abstract

Methamphetamine Toxicities and Clinical ManagementMethamphetamine increases the release and blocks the uptake of norepinephrine, serotonin, and dopamine. This article reviews the morbidity and mortality associated with methamphetamine use and discusses prevention and treatment strategies.

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Figures

Figure 1:
Figure 1:. Construct for Major Toxicities Produced by Methamphetamine Use
Figure 2:
Figure 2:. Addressing Methamphetamine Use in Clinical Care
Recommendations in italics remain hypothetical, with limited human or animal data *no FDA-approved medications for methamphetamine use disorder; all options are off-label
Figure 3:
Figure 3:. Diagnostic and Statistical Manual-V Criteria for Substance Use Disorder (SUD)
See this image and copyright information in PMC

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