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Editorial
. 2023 Nov;2(11):EVIDe2300222.
doi: 10.1056/EVIDe2300222. Epub 2023 Oct 24.

Host Receptor Targeting to Treat Covid-19

Jesper Damsgaard Gunst  1   2 , Ole Schmeltz Søgaard  1   2
Affiliations
Editorial

Host Receptor Targeting to Treat Covid-19

Jesper Damsgaard Gunst et al. NEJM Evid. 2023 Nov.

Abstract

Not long after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of coronavirus disease 2019 (Covid-19), in vitro experiments revealed that SARS-CoV-2 infection of human cells depended on the binding of the viral spike protein to the human cell-surface receptor angiotensin-converting enzyme 2 (ACE-2).1 Additional experiments demonstrated that infection could be blocked by inhibiting transmembrane protease, serine 2 (TMPRSS2), which is a host enzyme that cleaves the viral spike protein after binding to ACE-2 and facilitates entry of the virus into the host cell.

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  • A Randomized Trial of Nafamostat for Covid-19.
    Morpeth SC, Venkatesh B, Totterdell JA, McPhee GM, Mahar RK, Jones M, Bandara M, Barina LA, Basnet BK, Bowen AC, Burke AJ, Cochrane B, Denholm JT, Dhungana A, Dore GJ, Dotel R, Duffy E, Dummer J, Foo H, Gilbey TL, Hammond NE, Hudson BJ, Jha V, Jevaji PR, John O, Joshi R, Kang G, Kaur B, Kim S, Das SK, Lau JSY, Littleford R, Marsh JA, Marschner IC, Matthews G, Maze MJ, McArthur CJ, McFadyen JD, McMahon JH, McQuilten ZK, Molton J, Mora JM, Mudaliar V, Nguyen V, O'Sullivan MVN, Pant S, Park JE, Paterson DL, Price DJ, Raymond N, Rees MA, Robinson JO, Rogers BA, Ryu WS, Sasadeusz J, Shum O, Snelling TL, Sommerville C, Trask N, Lewin SR, Hills TE, Davis JS, Roberts JA, Tong SYC. Morpeth SC, et al. NEJM Evid. 2023 Nov;2(11):EVIDoa2300132. doi: 10.1056/EVIDoa2300132. Epub 2023 Oct 18. NEJM Evid. 2023. PMID: 38320527 Clinical Trial.

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