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Review
. 2024 Jan 20;32(1):83-86.
doi: 10.3760/cma.j.cn501113-20231130-00255.

[Clinical significance and research progress of quantitative hepatitis B virus core antibody measurement]

[Article in Chinese]
Y Q Liu  1 , C Zhang  1 , H Zhao  2 , G Q Wang  3
Affiliations
Review

[Clinical significance and research progress of quantitative hepatitis B virus core antibody measurement]

[Article in Chinese]
Y Q Liu et al. Zhonghua Gan Zang Bing Za Zhi. .

Abstract
in English, Chinese

Hepatitis B virus core antibodies are specific antibodies produced after viral infection that appear early and last for a long time, and its levels in serum are measured by the double-antigen sandwich chemiluminescent microparticle immunoassay method, which has higher sensitivity and specificity, providing new clinical indicators for hepatitis B patients diagnosis, treatment, and drug withdrawal management. This article reviews the clinical significance and research progress of quantitative hepatitis B core antibody measurement and expounds on its research applications and prospects in clinical practice.

乙型肝炎核心抗体是病毒感染后产生的特异性抗体，出现早，持续时间长，利用双抗原夹心化学发光微粒子免疫检测法测量其在血清中的水平，具有更高的灵敏度和特异性，为乙肝患者的诊断、治疗及停药管理提供新的临床指标。本文就乙肝核心抗体定量检测的临床意义及研究进展作综述，阐述其在临床实践中的研究应用及前景。.

Keywords: Liver fibrosis; Liver inflammation; Quantitative hepatitis B core antibody; Reactivation; Recurrence.

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