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Editorial
. 2024 Feb 1;13(1):115-118.
doi: 10.21037/hbsn-23-624. Epub 2024 Jan 17.

Heterogeneity in the risk of incident liver cirrhosis driven by PNPLA3 genotype and diabetes among different populations

Bo Kyung Koo  1   2 , Dong Hyeon Lee  2   3 , Jeong Hwan Park  4 , Won Kim  2   3
Affiliations
Editorial

Heterogeneity in the risk of incident liver cirrhosis driven by PNPLA3 genotype and diabetes among different populations

Bo Kyung Koo et al. Hepatobiliary Surg Nutr. .
No abstract available

Keywords: Nonalcoholic fatty liver disease (NAFLD); PNPLA3-rs738409; cirrhosis.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-23-624/coif). The authors report that this study was supported by Korea National Institute of Health (2022ER090700). The authors have no other conflicts of interest to declare.

Figures

Figure 1
Figure 1
The risk of fibrosis progression according to PNPLA3 rs738409 genotype and diabetes at baseline in FIB-4 <1.3, 1.3–2.67, and >2.67 at baseline. The cumulative incidence of fibrosis progression in patients with NAFLD, which was defined as LSM ≥9.6 kPa for patients with F0–2 at baseline and ΔLSM ≥+20% compared to the baseline level for patients with F3–4 at baseline during the follow-up period. FIB-4, fibrosis-4 index; DM, diabetes mellitus; HR, hazard ratio; CI, confidence interval; NAFLD, nonalcoholic fatty liver disease; LSM, liver stiffness measurement.
Figure 2
Figure 2
The ethnic difference in the risk of NAFLD according to PNPLA3 rs738409 genotype. Meta-analysis for the ethnic difference in the risk of NAFLD (A) and NASH among NAFLD subjects (B), according to PNPLA3 rs738409 genotype. OR, odds ratio; SE, standard error; CI, confidence interval; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis.
See this image and copyright information in PMC

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