Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Feb 3:2023:5410229.
doi: 10.1155/2023/5410229. eCollection 2023.

Aggressive Multiple Central Giant Cell Granulomas of the Jaws

Farnoush Mohammadi  1   2 , Hoorieh Bashizadehfakhar  3 , Sara Aliasghari  3 , Zahra Gholamhoseini  3
Affiliations
Case Reports

Aggressive Multiple Central Giant Cell Granulomas of the Jaws

Farnoush Mohammadi et al. Case Rep Dent. .

Abstract

Central giant cell granuloma (CGCG) is considered a benign intraosseous lesion with a varied range of clinical features in two subtypes, including aggressive and non-aggressive lesions. This study presents a 9-year-old boy with multiple bilateral CGCG in the mandible without any systemic disease or specific syndrome. Clinical, radiographic, and histopathological findings demonstrated the aggressive lesions. It is discussed how the differential diagnosis and treatment can be determined based on the patient's age as well as the size and manner of the lesion.

PubMed Disclaimer

Conflict of interest statement

The authors declare(s) that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The extraoral view of the patient.
Figure 2
Figure 2
The panoramic view.
Figure 3
Figure 3
The coronal (above) and axial sections (below) of post-contrast CT.
Figure 4
Figure 4
Scintigraphy of thyroid (left above), parathyroid (right above), and whole-body scan (left below).
Figure 5
Figure 5
Oval and spindle mononuclear cells (arrowhead) and clusters of multinuclear giant cells (arrows).
Figure 6
Figure 6
Oval and spindle mononuclear cells (arrowhead), clusters of multinuclear giant cells (arrows), and capillary (star).
Figure 7
Figure 7
The cross-sectional images in the CBCT scan.
See this image and copyright information in PMC

References

    1. Chrcanovic B. R., Gomes C. C., Gomez R. S. Central giant cell lesion of the jaws: an updated analysis of 2270 cases reported in the literature. Journal of Oral Pathology & Medicine . 2018;47(8):731–739. doi: 10.1111/jop.12730. - DOI - PubMed
    1. WHO Classification of Tumours, WHO Classification of Head and Neck Tumours: International Agency for Research on Cancer (IARC) 2017.
    1. Bredell M., Rordorf T., Kroiss S., Rücker M., Zweifel D. F., Rostetter C. Denosumab as a treatment alternative for central giant cell granuloma: a long-term retrospective cohort study. Journal of Oral and Maxillofacial Surgery . 2018;76(4):775–784. doi: 10.1016/j.joms.2017.09.013. - DOI - PubMed
    1. Lone P. A., Ahmed T., Ahmed T., Kumar V. Clinicopathologic features of central & peripheral giant cell lesions of oral cavity: our clinical experience. International Journal of Applied Research . 2016;2(10):29–33.
    1. Tecco S., Caruso S., Nota A., et al. Bilateral central giant cell granuloma of the mandibular angle in three females from the same family. Head & Face Medicine . 2018;14(1):1–8. doi: 10.1186/s13005-018-0171-7. - DOI - PMC - PubMed

Publication types

LinkOut - more resources