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Review
. 2024 Jan 19:14:1352273.
doi: 10.3389/fcimb.2024.1352273. eCollection 2024.

Strategies for combating antibiotic resistance in bacterial biofilms

Kayla E Grooters  1 , Jennifer C Ku  1 , David M Richter  1 , Matthew J Krinock  1 , Ashley Minor  1 , Patrick Li  2   3 , Audrey Kim  1 , Robert Sawyer  4 , Yong Li  3
Affiliations
Review

Strategies for combating antibiotic resistance in bacterial biofilms

Kayla E Grooters et al. Front Cell Infect Microbiol. .

Abstract

Biofilms, which are complexes of microorganisms that adhere to surfaces and secrete protective extracellular matrices, wield substantial influence across diverse domains such as medicine, industry, and environmental science. Despite ongoing challenges posed by biofilms in clinical medicine, research in this field remains dynamic and indeterminate. This article provides a contemporary assessment of biofilms and their treatment, with a focus on recent advances, to chronicle the evolving landscape of biofilm research.

Keywords: antibiotic resistance; bacteriophage; biofilm; infection; treatment.

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Conflict of interest statement

YL is an executive editor for Journal of Cellular Biochemistry. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of biofilm formation. Environmental conditions lead planktonic bacteria to utilize adhesion machinery to attach to a surface. Quorum sensing between colony members drives upregulation of extracellular matrix formation and changes in metabolic function, irreversibly cementing biofilm to surface and protecting the colony from environmental hazards (e.g., antiseptics, reactive oxygen species (ROS) and antibiotics. Figure made using Biorender.com.
See this image and copyright information in PMC

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