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. 2024 Jan 23:15:1293221.
doi: 10.3389/fendo.2024.1293221. eCollection 2024.

Insulin in the regulation of the renin-angiotensin system: a new perspective on the mechanism of insulin resistance and diabetic complications

Tatyana S Zamolodchikova  1 , Svetlana M Tolpygo  1 , Alexander V Kotov  1
Affiliations

Insulin in the regulation of the renin-angiotensin system: a new perspective on the mechanism of insulin resistance and diabetic complications

Tatyana S Zamolodchikova et al. Front Endocrinol (Lausanne). .
No abstract available

Keywords: angiotensin; diabetes mellitus; insulin; insulin resistance; renin-angiotensin system; signaling cross-talk.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Effect of insulin on RAS function. (A) Insulin affects central and local RAS by acting on their receptors, enzymes and angiotensin peptides (experimentally confirmed effects, details in the text of the article); ANG, angiotensin; AGT, angiotensinogen; ACE, angiotensin-converting enzyme; AT1R and AT2R, angiotensin receptors; IRAP, insulin-regulated aminopeptidase; (↑) – increasing; (↓) – reducing; (*) - high concentrations of insulin. (B) Mechanism of angiotensin-dependent IR as a vicious circle.
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