Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb 7;44(1):23.
doi: 10.1007/s10792-024-02928-x.

Evaluation and comparison of microperimetry and optical coherence tomography findings in patients with Behçet uveitis

Mehmet Fatih Kağan Değirmenci  1 , F Nilüfer Yalçındağ  2 , Ş Aysun İdil  2
Affiliations

Evaluation and comparison of microperimetry and optical coherence tomography findings in patients with Behçet uveitis

Mehmet Fatih Kağan Değirmenci et al. Int Ophthalmol. .

Abstract

Purpose: To evaluate and compare the findings of MP and OCT in patients with inactive Behçet's uveitis (BU).

Methods: Sixty-five eyes of 38 patients were included in this retrospective study. Ophthalmologic examination findings and OCT and MP results were recorded. The relationship between best corrected visual acuity (BCVA), duration of uveitis, central macular thickness (CMT), presence of photoreceptor zone (PZ), and/or retinal pigment epithelium (RPE) damage, macular integrity index, mean threshold and fixation stability was analyzed.

Results: There was a positive correlation between BCVA and CMT (p < 0.001). The eyes with PZ and/or RPE damage had significantly lower visual acuity (p < 0.001). There was a negative correlation between BCVA and macular integrity index (p = 0.005). BCVA showed positive correlations with mean threshold and fixation stability [(BCVA vs. mean threshold, p < 0.001), (BCVA vs. P1, p < 0.001), and (BCVA vs. P2, p < 0.001)]. While there was no significant correlation between CMT and macular integrity index (p = 0.08), both mean threshold and fixation stability were significantly positively correlated with CMT [(CMT vs. mean threshold, p = 0.01), (CMT vs. P1, p = 0.008), and (CMT vs. P2, p = 0.005)]. Mean threshold and fixation stability (P1 and P2) were significantly lower in the eyes with PZ and/or RPE damage (p = 0.008, p = 0.02, and p = 0.01, respectively).

Conclusion: MP showed results consistent with visual acuity and morphological findings by OCT in patients with inactive BU. Although MP is promising for patient follow-up, controlled prospective studies are needed.

Keywords: Behçet uveitis; Microperimetry; Optical coherence tomography; Photoreceptor zone; Retinal pigment epithelium.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Zakka FR, Chang PY, Giuliari GP et al (2009) Current trends in the management of ocular symptoms in Adamantiades-Behçet’s disease. Clin Ophthalmol 3:567–579 - PubMed - PMC
    1. Mendes D, Correia M, Barbedo M et al (2009) Behçet’s disease—a contemporary review. J Autoimmun 32(3–4):178–188 - DOI - PubMed
    1. Strouthidis NG, Grimm J, Williams GA et al (2010) A comparison of optic nerve head morphology viewed by spectral domain optical coherence tomography and by serial histology. Invest Ophthalmol Vis Sci 51(3):1464–1474 - DOI - PubMed - PMC
    1. Yiu G, Wang Z, Munevar C et al (2018) Comparison of chorioretinal layers in rhesus macaques using spectral-domain optical coherence tomography and high-resolution histological sections. Exp Eye Res 168:69–76 - DOI - PubMed - PMC
    1. Markowitz SN, Reyes SV (2013) Microperimetry and clinical practice: an evidence-based review. Can J Ophthalmol 48(5):350–357 - DOI - PubMed

LinkOut - more resources