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. 2024 Feb 7;51(1):282.
doi: 10.1007/s11033-024-09225-x.

Evaluation of circulating levels of miR-135a and miR-193 in patients with sepsis

Nazila Behroozizad  1 , Ata Mahmoodpoor  1 , Kamran Shadvar  1 , Roghayeh Asghari Ardebil  1 , Aynour Jalali Pahnvar  2 , Nasim Sohrabifar #  3 , Somayeh Kazeminasab #  4   5
Affiliations

Evaluation of circulating levels of miR-135a and miR-193 in patients with sepsis

Nazila Behroozizad et al. Mol Biol Rep. .

Abstract

Background: Sepsis is a life-threatening condition where early diagnosis and prognostic awareness provide guidance for selecting the appropriate treatment strategies. A wide variety of biomarker-based studies in clinical medicine provide new insights into personalized medicine for sepsis patients. MiRNAs are endogenous non-coding RNA molecules that have been acting as great potential diagnostic, prognostic and therapeutic biomarkers in various diseases.

Methods and results: In the present study, the expression levels of two selected miRNAs, including miR-135a and miR-193, were evaluated for their prognostic potential in patients with sepsis. The circulating levels of miRNAs were quantified by quantitative PCR (qPCR) in patients with sepsis (n = 100) and age- and sex-matched healthy controls (n = 100). Statistical findings confirmed the valuable prognostic potential of miR-135a in patients with sepsis, while no significant difference was found between the miR-193 expression level in the patients with sepsis and the controls.

Conclusions: Circulating levels of miRNA-135a can serve a the prognostic biomarker for patients with sepsis. These findings highlight the importance of miRNAs as signatures in the personalized managements of sepsis.

Keywords: Biomarker; Sepsis; miR-135a; miR-193; miRNA.

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