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Meta-Analysis
. 2024 Feb 5:39:e390424.
doi: 10.1590/acb390424. eCollection 2024.

Antibiotics prophylaxis at the time of catheter removal after radical prostatectomy: a systematic review of the literature and meta-analysis

Letícia Lourenço Dos Santos  1 , Isabela de Almeida Fraga  1 , Vitor Amaral de Almeida  1 , Andressa Hellen Ribeiro Santos  1 , Isabelle Matos Almeida  1 , Tatiana Roberta Nascimento  1 , Breno Cordeiro Porto  2 , Carlo Camargo Passerotti  2   3 , Everson Luiz de Almeida Artifon  2 , Jose Pinhata Otoch  2 , José Arnaldo Shiomi da Cruz  1   2   3
Affiliations
Meta-Analysis

Antibiotics prophylaxis at the time of catheter removal after radical prostatectomy: a systematic review of the literature and meta-analysis

Letícia Lourenço Dos Santos et al. Acta Cir Bras. .

Abstract

Purpose: To conduct a systematic literature review with meta-analysis to identify whether antibiotic prophylaxis after removal of the indwelling urinary catheter reduces posterior infections.

Methods: A systematic literature review was conducted in the databases PubMed, Embase, Cochrane, Google Scholar, and Latin American and Caribbean Health Sciences Literature, using the keywords "antibiotics" AND "prostatectomy" AND "urinary catheter."

Results: Three articles were identified having the scope of our review, with 1,040 patients, which were subjected to our meta-analysis revealing a marginally significant decrease in the risk of urinary infection after indwelling urinary catheter removal (odds ratio-OR = 0.51; 95% confidence interval-95%CI 0.27-0.98; p = 0.04; I2 = 0%). No difference was found regarding the presence of bacteriuria (OR = 0.39; 95%CI 0.12-1.24; p = 0.11; I2 = 73%).

Conclusions: In our meta-analysis, there was a significant decrease in urinary tract infection with antibiotic prophylaxis after indwelling urinary catheter removal following radical prostatectomy.

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Conflict of interest statement

Conflict of interest: Nothing to declare.

Figures

Figure 1
Figure 1. Preferred reporting Items for Systematic Reviews and Meta-Analysis diagram with the results found in the research.
Figura 4
Figura 4. Risk of Bias assessment. (a) Risk of bias RoB 2 tool of the included RCT studies. (b) Risk of bias ROBINS-I of the included non-RCT study.
See this image and copyright information in PMC

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