Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Dec 12;24(1):56-58.
doi: 10.1177/15357597231210253. eCollection 2024 Jan-Feb.

Only Hit the Bad Guys: A Gene Therapy Approach to Selectively Silence Highly Active Neurons Reduces Chronic Seizures in Epileptic Mice

Affiliations
Comment

Only Hit the Bad Guys: A Gene Therapy Approach to Selectively Silence Highly Active Neurons Reduces Chronic Seizures in Epileptic Mice

Tristan Shuman. Epilepsy Curr. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Comment on

  • On-demand cell-autonomous gene therapy for brain circuit disorders.
    Qiu Y, O'Neill N, Maffei B, Zourray C, Almacellas-Barbanoj A, Carpenter JC, Jones SP, Leite M, Turner TJ, Moreira FC, Snowball A, Shekh-Ahmad T, Magloire V, Barral S, Kurian MA, Walker MC, Schorge S, Kullmann DM, Lignani G. Qiu Y, et al. Science. 2022 Nov 4;378(6619):523-532. doi: 10.1126/science.abq6656. Epub 2022 Nov 3. Science. 2022. PMID: 36378958 Free PMC article.

References

    1. Shaimardanova AA, Chulpanova DS, Mullagulova AI, et al. Gene and cell therapy for epilepsy: a mini review. Front Mol Neurosci. 2022;15:868531. - PMC - PubMed
    1. Qiu Y, O’Neill N, Maffei B, et al. On-demand cell-autonomous gene therapy for brain circuit disorders. Science. 2022;378(6619):523–532. doi:10.1126/science.abq6656 - PMC - PubMed
    1. Chen BK, Murawski NJ, Cincotta C, et al. Artificially enhancing and suppressing hippocampus-mediated memories. Current Biology. 2019; 29(11):1885–1894. - PMC - PubMed
    1. Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S. Ventral CA1 neurons store social memory. Science. 2016;353(6307):1536–1541. - PMC - PubMed
    1. Terranova JI, Yokose J, Osanai H, et al. Hippocampal-amygdala memory circuits govern experience-dependent observational fear. Neuron. 2022;110(8):1416–1431. - PMC - PubMed