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. 2023 Dec;16(12):2440-2445.
doi: 10.14202/vetworld.2023.2440-2445. Epub 2023 Dec 16.

Effects of Solanum tuberosum L. ointment on second-degree burns in mice

Carmen R Silva-Correa  1 , Galy P Rosas-Cruz  1 , Abhel A Calderón-Peña  2 , Víctor E Villarreal-La Torre  1 , Cinthya L Aspajo-Villalaz  2 , Julio A Castañeda-Carranza  3 , Deivy Y Dionicio-Rosado  3 , Ricardo M Gómez-Arce  3 , Cristhian N Rodríguez-Silva  2 , Jorge Del Rosario-Chávarri  2 , José L Cruzado-Razco  1
Affiliations

Effects of Solanum tuberosum L. ointment on second-degree burns in mice

Carmen R Silva-Correa et al. Vet World. 2023 Dec.

Abstract

Background and aim: Potato (Solanum tuberosum L.) is mainly characterized by its antioxidant and healing properties. Therefore, this study aimed to evaluate the effects of an ointment based on S. tuberosum L. "papa tumbay" on burns induced in Balb/c mice (Mus musculus).

Materials and methods: The experimental animals were divided into four groups (n = 5/group) 48 h before second-degree burns were inducted. After epilating the loin areas of the mice and anesthetizing them with ketamine/xylazine (80 mg/kg/10 mg/kg) through intraperitoneal (i.p.) route, a round metal rod (0.7 cm in diameter) was placed on the depilated skin at a temperature of 100°C for 5 s. Group I was not given any treatment, Group II was treated with silver sulfadiazine (1%), and the other two groups (III and IV) were treated with the ointment formulated based on S. tuberosum L. "papa tumbay" at 1% and 2%, respectively. After performing the treatment for 21 days, the mice were euthanized using i.p. sodium pentobarbital (185 mg/kg) to obtain skin samples. The samples were preserved in 10% neutral-buffered formalin and subjected to histopathological analysis.

Results: We found statistically significant differences in the histopathological sections between the groups (p < 0.05). The abundant collagen and fibroblasts observed in the direction of the dermis in Groups III and IV indicate that the phytoconstituents present in the potato might promote the healing of the second-degree burns until day 21 of treatment.

Conclusion: Our findings showed that the ointments based on the ethanolic extracts of S. tuberosum L. "papa tumbay," especially the 2% ointment, might accelerate the healing of second-degree burns induced in Balb/c mice.

Keywords: Solanum tuberosum L; burn healing; herbal medicine; histopathology; ointment; potato; skin.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure-1
Figure-1
Percentage of healing of second-degree burns induced in Mus musculus Balb/c. in the experimental groups. p < 0.05, n = 5.
Figure-2
Figure-2
Histopathological skin sections of Mus musculus Balb/c. (a) Group I (Control). (b) Group II (silver sulfadiazine). (c) Group III (Ointment Solanumtuberosum 1%). (d) Group IV (Ointment S. tuberosum 2%). Keratinous stratum corneum (CE), Stratum granularis (EG), Sweat glands (GS), Stratum spinosum (EE), Basal cells (EB), and fibroblasts (*) (Hematoxylin and Eosin, 400×).
See this image and copyright information in PMC

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