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. 2024 Feb 16;89(4):2200-2211.
doi: 10.1021/acs.joc.3c02094. Epub 2024 Feb 8.

Electrochemical Oxidative Dearomatization Strategy for Accessing Spiro[4.5]dienones and Derivatives

Rohan Bag  1 , Nilima Priyadarsini Mishra  1 , Debarshi Saha  1 , Prabal Banerjee  1
Affiliations

Electrochemical Oxidative Dearomatization Strategy for Accessing Spiro[4.5]dienones and Derivatives

Rohan Bag et al. J Org Chem. .

Abstract

Electrochemical dearomatization has been recognized as an attractive tool for the rapid construction of structurally diverse molecules. The designed methodology encompasses an eco-friendly and efficient electrochemical approach to synthesizing spiro[4.5]dienones under mild reaction conditions. Furthermore, detailed mechanistic studies strongly bolster our hypothesis and emphasize the role of HFIP in the mechanism. The protocol is scalable and showcases a broad substrate scope with tolerance toward numerous functional groups. Henceforth, this strategy can be deployed as an alternative and sustainable tool for accessing spiro[4.5]dienones.

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