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. 2024 Apr 15;209(8):1031-1033.
doi: 10.1164/rccm.202310-1751LE.

Biomarkers Associated with Lung Function Decline and Dupilumab Response in Patients with Asthma

Ian D Pavord  1 , Lucia De Prado Gómez  2 , Guy Brusselle  3 , Daniel J Jackson  4 , Christopher E Brightling  5 , Alberto Papi  6 , Jorge F Maspero  7 , Klaus F Rabe  8   9 , Stephanie Korn  10 , Mei Zhang  11 , Xavier Soler  12 , Juby A Jacob-Nara  11 , Megan Hardin  13 ; QUEST Lung Function Decline Study Group
Collaborators, Affiliations

Biomarkers Associated with Lung Function Decline and Dupilumab Response in Patients with Asthma

Ian D Pavord et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Rate of lung function decline across baseline FeNO levels. The slope difference between the two lines is −11.8, with a 95% confidence interval of −71.5, 47.8. BD = bronchodilator; FeNO = fractional exhaled nitric oxide; ppb = parts per billion.
Figure 2.
Figure 2.
Lung function decline difference in populations selected by combined baseline FeNO and eosinophil levels. *Estimated from a mixed-effects model with repeated post-BD FEV1 as outcome, and treatment, age, sex, height, region (pooled country), baseline eosinophil strata, baseline ICS dose level, time since randomization, and Treatment × Time interaction and baseline post-BD FEV1 as covariates. Intercept and time since randomization are random effects. BD = bronchodilator; FeNO = fractional exhaled nitric oxide; FEV1 = forced expiratory volume in one second; SE = standard error.
See this image and copyright information in PMC

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