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Review
. 2024 Mar;108(2):339-354.
doi: 10.1016/j.mcna.2023.09.002. Epub 2023 Nov 1.

Proctitis: An Approach to the Symptomatic Patient

Candice J McNeil  1 , Luis F Barroso 2nd  2 , Kimberly Workowski  3
Affiliations
Review

Proctitis: An Approach to the Symptomatic Patient

Candice J McNeil et al. Med Clin North Am. 2024 Mar.

Abstract

Proctitis is an inflammatory condition of the distal rectum that can be associated with common sexually transmitted infections (STIs), such as gonorrhea, chlamydia, and syphilis. For persons presenting with ulcerative findings on examination, in addition to syphilis, Mpox, lymphogranuloma venereum, and herpes simplex virus should be in the differential. Providers should also be aware that there are evolving data to support a role for Mycoplasma genitalium in proctitis. Performing a comprehensive history, clinical evaluation including anoscopy, and rectal nucleic amplification STI testing may be useful in identifying the cause of proctitis and targeting treatment.

Keywords: Prevention; Proctitis; Sexually transmitted infection; Treatment.

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Conflict of interest statement

Disclosures In the past 12 months, C.J. McNeil has received research grants or contracts from Centers for Disease Control and Prevention, BARDA, United States/GSK, Becton Dickinson (BD), Cepheid, United States, Gilead, Hologic, United States, National Institutes of Health, United States paid to Wake Forest University School of Medicine. C.J. McNeil is on the advisory board for Talis Biomedical. L.F. Barroso has received grants or contracts funding from the National Institutes of Health and the AIDS Malignancy Consortium paid to Wake Forest University School of Medicine. K. Workowski has received grants or contracts from Gilead, Abbvie, United States, Centers for Disease Control and Prevention, United States, National Institutes of Health paid to Emory University.

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