A potential compensatory mechanism for spaceflight associated neuro-ocular changes from microgravity: current understanding and future directions

Benjamin Soares¹, Joshua Ong², Daniela Osteicoechea³, Cihan Mehmet Kadipasaoglu⁴, Ethan Waisberg⁵, Prithul Sarker⁶, Nasif Zaman⁶, Alireza Tavakkoli⁶, Gianmarco Vizzeri⁷, Andrew G Lee^{8

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Affiliations

¹ Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
² Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, MI, USA.
³ Texas A&M School of Medicine, Bryan, TX, USA.
⁴ Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA.
⁵ Department of Ophthalmology, University of Cambridge, Cambridge, UK.
⁶ Human-Machine Perception Laboratory, Department of Computer Science and Engineering, University of Nevada, Reno, Reno, NV, USA.
⁷ Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA.
⁸ Texas A&M School of Medicine, Bryan, TX, USA. ew690@cam.ac.uk.
⁹ Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA. ew690@cam.ac.uk.
¹⁰ Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA. ew690@cam.ac.uk.
¹¹ Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA. ew690@cam.ac.uk.
¹² The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA. ew690@cam.ac.uk.
¹³ Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY, USA. ew690@cam.ac.uk.
¹⁴ University of Texas MD Anderson Cancer Center, Houston, TX, USA. ew690@cam.ac.uk.
¹⁵ Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA. ew690@cam.ac.uk.

Editorial

Benjamin Soares et al. Eye (Lond). 2024 Jun.

. 2024 Jun;38(9):1605-1607.

doi: 10.1038/s41433-024-02952-2. Epub 2024 Feb 8.

¹ Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
² Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, MI, USA.
³ Texas A&M School of Medicine, Bryan, TX, USA.
⁴ Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA.
⁵ Department of Ophthalmology, University of Cambridge, Cambridge, UK.
⁶ Human-Machine Perception Laboratory, Department of Computer Science and Engineering, University of Nevada, Reno, Reno, NV, USA.
⁷ Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA.
⁸ Texas A&M School of Medicine, Bryan, TX, USA. ew690@cam.ac.uk.
⁹ Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA. ew690@cam.ac.uk.
¹⁰ Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA. ew690@cam.ac.uk.
¹¹ Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA. ew690@cam.ac.uk.
¹² The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA. ew690@cam.ac.uk.
¹³ Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY, USA. ew690@cam.ac.uk.
¹⁴ University of Texas MD Anderson Cancer Center, Houston, TX, USA. ew690@cam.ac.uk.
¹⁵ Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA. ew690@cam.ac.uk.

No abstract available

Conflict of interest statement

Andrew G. Lee, is a consultant for the National Aeronautics and Space Administration (NASA).

1. Human Research Roadmap [Internet]. [cited 2023 Nov]. Available from: https://humanresearchroadmap.nasa.gov/.
1. Patel ZS, Brunstetter TJ, Tarver WJ, Whitmire AM, Zwart SR, Smith SM, et al. Red risks for a journey to the red planet: the highest priority human health risks for a mission to Mars. NPJ Microgravity. 2020;6:1–13. doi: 10.1038/s41526-020-00124-6. - DOI - PMC - PubMed
1. Lee AG, Mader TH, Gibson CR, Tarver W, Rabiei P, Riascos RF, et al. Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update. NPJ Microgravity. 2020;6:7. doi: 10.1038/s41526-020-0097-9. - DOI - PMC - PubMed
1. Lee AG, Tarver WJ, Mader TH, Gibson CR, Hart SF, Otto CA. Neuro-ophthalmology of space flight. J Neuro-Ophthalmol J North Am Neuro-Ophthalmol Soc. 2016;36:85–91. doi: 10.1097/WNO.0000000000000334. - DOI - PubMed
1. Mader TH, Gibson CR, Pass AF, Kramer LA, Lee AG, Fogarty J, et al. Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology. 2011;118:2058–69. doi: 10.1016/j.ophtha.2011.06.021. - DOI - PubMed