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. 2024 Feb 3:20:211-220.
doi: 10.2147/NDT.S442459. eCollection 2024.

18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia

Feng Wang #  1 , Shu-Ting Hong #  1 , Ying Zhang  2 , Zhen Xing  3 , Yuan-Xiang Lin  1
Affiliations

18F-FDG-PET/CT for Localizing the Epileptogenic Focus in Patients with Different Types of Focal Cortical Dysplasia

Feng Wang et al. Neuropsychiatr Dis Treat. .

Abstract

Purpose: To determine the diagnostic and localization value of 18F-fluorodeoxyglucose-positron emission tomography (PET)/computed tomography (CT) in patients with focal cortical dysplasia (FCD) who underwent epilepsy surgery.

Methods: One hundred and eight patients with pathologically proven FCD who underwent surgery for refractory epilepsy were retrospectively analyzed. All patients underwent magnetic resonance imaging (MRI), 18F-FDG-PET/CT, and video electroencephalography. An MRI diagnosis of FCD was defined as MRI+. A PET/CT diagnosis of FCD was defined as PET/CT+.

Results: MRI and PET/CT detected FCD in 20.37% and 93.52% of patients, respectively. The difference was significant. Twenty-one patients were MRI+/PET+, 80 were MRI-/PET+, six were MRI-/PET-, and one was MRI+/PET-. The MRI positivity rate was lowest in patients with FCD type IIIa (5.6%, P < 0.05). Prevalence of MRI-/PET+ was highest in patients with FCD type IIIa (88.89%, P < 0.05).

Conclusion: PET/CT is superior to MRI in detecting FCD. FCD type IIIa was more likely than other types to show MRI-/PET+. This suggests that PET/CT has particular diagnostic value for FCD type IIIa patients with negative MRI findings.

Keywords: 18F-FDG-PET/CT; epilepsy; focal cortical dysplasia; pathological types.

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Conflict of interest statement

The authors have no competing interests.

Figures

Figure 1
Figure 1
MRI results of different pathological types of FCD.
Figure 2
Figure 2
PET/CT results of different pathological types of FCD.
Figure 3
Figure 3
The combined results of MRI and PET/CT of different pathological types of FCD.
See this image and copyright information in PMC

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