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. 2024 Jan 20;10(3):e24824.
doi: 10.1016/j.heliyon.2024.e24824. eCollection 2024 Feb 15.

Research trends on airway remodeling: A bibliometrics analysis

Pengcheng Liu  1 , Yu Wang  1 , Chen Chen  1 , Hui Liu  1 , Jing Ye  1 , Xiaoming Zhang  2 , Changxiu Ma  1 , Dahai Zhao  1
Affiliations

Research trends on airway remodeling: A bibliometrics analysis

Pengcheng Liu et al. Heliyon. .

Abstract

Background: Airway remodeling is an essential pathological basis of respiratory diseases such as asthma and COPD, which is significantly related to pulmonary function and clinical symptoms. And pulmonary disease can be improved by regulating airway remodeling. This study aimed to establish a knowledge map of airway remodeling to clarify current research hotspots and future research trends.

Methods: A comprehensive search was performed to analyze all relevant articles on airway remodeling using the Web of Science Core Collection Database from January 01, 2004 to June 03, 2023.2 reviewers screened the retrieved literature. Besides, the CiteSpace (6.2. R3) and VOSviewer (1.6.19) were utilized to visualize the research focus and trend regarding the effect of airway remodeling.

Results: A total of 4077 articles about airway remodeling were retrieved. The United States is the country with the most published literature, underscoring the country's role in airway remodeling. In recent years, China has been the country with the fastest growth in the number of published literature, suggesting that China will play a more critical role in airway remodeling in the future. From the perspective of co-operation among countries, European co-operation was closer than Asian co-operation. The co-citation analysis showed that 98,313 citations were recorded in 3594 articles, and 25 clusters could be realized. In recent years, Burst detection shows that oxidative stress and epithelial-mesenchymal transition are hot words.

Conclusions: Based on the bibliometric analysis of airway remodeling studies in the past 20 years, a multi-level knowledge structure map was drawn, it mainly includes countries, institutions, research fields, authors, journals, keywords and so on. The research directions represented by obstructive airway disease, PDGF-BB treatment of airway smooth muscle, allergen-induced airway remodeling, extracellular matrix, and non-coding RNA are the research hotspots in the field of airway remodeling. While the risk factors for airway remodeling, the application of new noninvasively assessing tools, biomarkers as well as The molecular mechanism represented by EMT and autophagy had been frontiers in recent years.

Keywords: Airway remodeling; Asthma; Bibliometric analysis; COPD; Citespace; VOSviewer.

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Conflict of interest statement

The authors declare no conflict of interest.The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
The statistics of airway remodeling-related articles from 2004 to 2023.
Fig. 2
Fig. 2
Co-operation among countries that published airway remodeling-related studies.
Fig. 3
Fig. 3
Co-operation among countries that published airway remodeling articles-related studies. A: Top 20 countries that published airway remodeling articles-related studies; B: top 10 countries with the strongest citation bursts; C–H: Annual number of airway remodeling-related studies in each country. The red colour shown on the right side of Fig. 3B indicates that references were highly cited in a short period.
Fig. 4
Fig. 4
Co-operation among institutions that published airway remodeling-related studies.
Fig. 5
Fig. 5
Top institutions that published airway remodeling-related studies. A: Top 20 institutions publishing in airway remodeling-related studies; B: Top 25 institutions with the strongest citation bursts that published airway remodeling-related studies. The red colour shown on the right side of Fig. 5B indicates that references were highly cited in a short period.
Fig. 6
Fig. 6
Research areas of airway remodeling-related studies.
Fig. 7
Fig. 7
Co-operation among authors that published airway remodeling-related studies.
Fig. 8
Fig. 8
Top 25 Cited Authors with the Strongest Citation Bursts. The red colour shown on the right side of the figure indicates that references were highly cited in a short period.
Fig. 9
Fig. 9
The dual-map overlay of journals on airway remodeling-related studies.
Fig. 10
Fig. 10
Co-citation analysis of airway remodeling-related studies. The results of clusters are shown on the right side. The colour represents when the cluster appears. The red point represents the citation/frequency burst.
Fig. 11
Fig. 11
Top 25 References with the Strongest Citation Bursts. The red colour shown on the right side of the figure indicates that references were highly cited in a short period.
Fig. 12
Fig. 12
Co-occurrence network of airway remodeling keywords.
Fig. 13
Fig. 13
Clustering network of airway remodeling keywords.
Fig. 14
Fig. 14
Top 30 Keywords with the Strongest Citation Bursts. The red colour shown on the right side of the figure indicates that references were highly cited in a short period.
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