Toxicity Following Tranexamic Acid Overdose

James Chenoweth^{1

2}, Stacy Marshall³, Justin Lewis^{4

5}, Timothy Albertson^{4

6}

Affiliations

¹ Department of Emergency Medicine, Division of Medical Toxicology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA. jachenoweth@ucdavis.edu.
² California Poison Control System - Sacramento Division, Sacramento, CA, USA. jachenoweth@ucdavis.edu.
³ Department of Emergency Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
⁴ California Poison Control System - Sacramento Division, Sacramento, CA, USA.
⁵ University of California San Francisco School of Pharmacy, San Francisco, CA, USA.
⁶ Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, CA, USA.

James Chenoweth et al. J Med Toxicol. 2024 Apr.

. 2024 Apr;20(2):215-217.

doi: 10.1007/s13181-024-00989-z. Epub 2024 Feb 9.

James Chenoweth^{1

2}, Stacy Marshall³, Justin Lewis^{4

5}, Timothy Albertson^{4

6}

¹ Department of Emergency Medicine, Division of Medical Toxicology, University of California Davis School of Medicine, Sacramento, CA, 95817, USA. jachenoweth@ucdavis.edu.
² California Poison Control System - Sacramento Division, Sacramento, CA, USA. jachenoweth@ucdavis.edu.
³ Department of Emergency Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
⁴ California Poison Control System - Sacramento Division, Sacramento, CA, USA.
⁵ University of California San Francisco School of Pharmacy, San Francisco, CA, USA.
⁶ Department of Internal Medicine, University of California Davis School of Medicine, Sacramento, CA, USA.

No abstract available

Conflict of interest statement

None.

1. Tranexamic acid in sodium chloride. Package Insert. Exela Pharma Sciences, LLC. 2019. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212020lbl.pdf. Accessed June 28 2023.
1. Lysteda. Package Insert. Ferring Pharmaceuticals Inc. 2020. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022430s009lbl.pdf. Accessed June 28 2023.
1. Roberts I, Shakur H, Coats T, Hunt B, Balogun E, Barnetson L, et al. The CRASH-2 trial: A randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. Health Technol Assess. 2013;17(10):1–79. doi: 10.3310/hta17100. - DOI - PMC - PubMed
1. Heyns M, Knight P, Steve AK, Yeung JK. A single preoperative dose of tranexamic acid reduces perioperative blood loss: A meta-analysis. Ann Surg. 2021;273(1):75–81. doi: 10.1097/SLA.0000000000003793. - DOI - PubMed
1. Chiang CY, Lin JS, Tsai TY, Tu YK, Tsai MJ. Comparative effectiveness of various noninvasive local treatments in patients with epistaxis: a systematic review and network meta-analysis. Acad Emerg Med. 2023 doi: 10.1111/acem.14680. - DOI - PubMed