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Randomized Controlled Trial
. 2024 May 8;116(5):758-763.
doi: 10.1093/jnci/djae027.

Geriatric assessment and quality of life for 2 years in older patients with head and neck cancer

Charlotte Lafont  1   2 , Elena Paillaud  1   3 , Chloe Bertolus  4 , Melany Baron  5 , Philippe Caillet  1   3 , Eric Bouvard  6 , Marie Laurent  1   7 , Didier Salvan  8 , Laurence Chaumette  9 , Laure de Decker  10 , Benoit Piot  11 , Beatrix Barry  12 , Agathe Raynaud-Simon  13 , Elisabeth Sauvaget  14 , Aurélien Minard  15 , Amélie Anota  16   17 , Henri Panjo  18 , Lydia Brugel  19 , Florence Canouï-Poitrine  1   2
Affiliations
Randomized Controlled Trial

Geriatric assessment and quality of life for 2 years in older patients with head and neck cancer

Charlotte Lafont et al. J Natl Cancer Inst. .

Abstract

Due to the location and toxicity of treatments, head and neck cancer (HNC) has a major impact on quality of life (QoL). Objective: to assess the effects of geriatric-assessment (GA)-driven interventions on QoL over 2 years in older adults with HNC.EGeSOR was a randomized study of HNC patients aged ≥65, receiving a pretreatment GA, a geriatric intervention and follow-up (intervention) or standard of care (control). The primary endpoint was QoL score using the European Organisation for Research and Treatment of Cancer's (EORTC QLQ-C30) and HNC (QLQ-HN35) QoL questionnaires over 24 months.In total, 475 patients were included (median age: 75.3; women: 31%; oral cancer: 44%). QoL scores improved over 24 months with various trajectories, without significant differences between the groups. A total of 74% of patients (interventional group) did not receive the complete intervention. Cancer characteristics, functional status, and risk of frailty were associated with change in the Global Health Status QoL score.There is a need to develop an alternative model of implementation such as patient-centered health-care pathways.

Trial registration: NCT02025062.

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