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. 2024 Feb 9;25(1):87.
doi: 10.1186/s12931-023-02625-w.

Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response

Caroline Sevoz-Couche  1 , Maxime Patout  2   3   4 , Beny Charbit  5   6 , Thomas Similowski  2   7 , Christian Straus  2   8
Affiliations

Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response

Caroline Sevoz-Couche et al. Respir Res. .

Abstract

After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment.Clinical Trials Identifier NCT01243697.

Keywords: Autonomic nervous system; Desogestrel; Heart rate variability; Hypoventilation syndrome.

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Conflict of interest statement

Dr. T. SIMILOWSKI reports personal fees for consulting and teaching activities from AstraZeneca France, Chiesi France, KPL consulting, Lungpacer Inc., OSO-AI, TEVA France, Vitalaire, all outside the present study. He is a stock shareholder of startups Hephaï and Austral Dx, which bear no relationship with the present study. He is listed as inventor on several patents, granted or pending, without relationship with the present study. Dr M. PATOUT reports grants or contracts from Fisher & Paykel, Resmed and Asten Santé, and personal fees for consulting and teaching activities from Philips Respironics, Resmed, Asten Santé, GSK, Vitalaire, SOS Oxygene, Chiesi, Elivie, Breas, Bastide, Air Liquide Medical, Antadir, Jazz Pharmaceuticals, Loewenstein, all outside the present study. He also reports support for attending meetings and/or travel from Asten Santé et Vitalaire, and participates on Data Safety Monitoring Board or Advisory Board of Philips Respironics, Resmed, Asten Santé, as well as receipt of equipment, materials, drugs or other services form Philips Respironics, Resmed and Fisher & Paykel, all without relationship with the present study. He is a stock shareholder of Kernel Biomedical which bears no relationship with the present study. Dr C. STRAUS reports grant and support from Centre Hospitalier de Lille and CARMAT, without relationship with the study.

Figures

Fig. 1
Fig. 1
Qualitative beat-to-beat analysis of RR-intervals during steady state air breathing (normoxia) using Poincaré analysis and Frequential analysis. Note the higher dispersion of points in Poincare ellipses in Patients 4 and 5 (responsive to Rebreathing) compared to the others (non-responsive to Rebreathing), indicating higher heart rate variability in these patients
Fig. 2
Fig. 2
Poincaré indexes and Frequential parameters during and steady-state air breathing (normoxia) and CO2 challenge. Increases in vagal SD1 during hypercapnia were seen in Group 1 patients only, with or without (washout) treatment
See this image and copyright information in PMC

References

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