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. 2024 Feb 9;29(1):111.
doi: 10.1186/s40001-024-01696-9.

Causal relationships between delirium and Parkinson's disease: a bidirectional two-sample Mendelian randomization study

Xiaoliang Bai  1 , Anna Zhang  2 , Qingbo Zhou  3 , Hongli Wang  4
Affiliations

Causal relationships between delirium and Parkinson's disease: a bidirectional two-sample Mendelian randomization study

Xiaoliang Bai et al. Eur J Med Res. .

Abstract

Background: Previous observational studies have suggested a notably elevated prevalence of delirium in individuals diagnosed with Parkinson's disease (PD), thereby implying a potential increased susceptibility to delirium among PD patients. However, it is imperative to acknowledge that observational studies inherently possess limitations, rendering it arduous to establish a definitive causal or reverse causal association between delirium and PD.

Methods: To explore the relationship between delirium and PD, a bidirectional two-sample Mendelian randomization (MR) was conducted using summary statistics obtained from genome-wide association studies. The main analysis was performed using the inverse-variance weighted (IVW) method, with further analyses conducted using MR Egger, weighted median, and weighted mode to ensure accuracy of findings. Additionally, Cochran's Q statistics and MR Egger intercept were utilized to assess heterogeneity and horizontal pleiotropy, respectively.

Results: According to the results obtained from the IVW model, no compelling evidence was found to support a potential causal association between delirium and PD (IVW: odds ratio [OR]: 0.996, 95% confidence interval CI 0.949-1.043, P = 0.845). Additionally, in the reverse direction, based on the results obtained from the IVW model, no significant evidence was found to support a causal association between PD and delirium (IVW: OR: 1.078, 95%CI 0.960-1.204, P = 0.225). A sensitivity analysis verified the reliability of the results.

Conclusion: According to the MR findings, a bidirectional causal relationship between delirium and PD is not observed. It is crucial to conduct further research in clinical practice to investigate the association between delirium and the risk of PD.

Keywords: Causal relationships; Delirium; Mendelian randomization; Parkinson’s disease.

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Conflict of interest statement

The authors declare no interest.

Figures

Fig. 1
Fig. 1
Overall design of Mendelian randomization analyses
Fig. 2
Fig. 2
Scatter plot of genetic correlation between PD and delirium using four MR methods. A Evaluation the effect of delirium on PD. B Evaluation the effect of PD on delirium. PD Parkinson’s disease, MR Mendelian randomization
Fig. 3
Fig. 3
Leave-one-out analysis of the MR results between PD and delirium. A Delirium on PD. B AD on delirium. PD Parkinson’s disease, MR Mendelian randomization
See this image and copyright information in PMC

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