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. 2024 Jan 25;13(3):708.
doi: 10.3390/jcm13030708.

How to Manage Advanced Differentiated Thyroid Cancer: Step-by-Step Analysis from Two Italian Tertiary Referral Centers

Paola Vincenza Sartori  1 , Sara Andreani  2 , Loredana De Pasquale  3 , Iuliana Pauna  2 , Antonio Mario Bulfamante  4 , Paolo Salvatore Lorenzo Aiello  2 , Rossella Melcarne  5 , Laura Giacomelli  6 , Marco Boniardi  2
Affiliations

How to Manage Advanced Differentiated Thyroid Cancer: Step-by-Step Analysis from Two Italian Tertiary Referral Centers

Paola Vincenza Sartori et al. J Clin Med. .

Abstract

Background: Differentiated thyroid carcinoma (DTC) has an excellent prognosis; however, advanced disease is associated with a worse prognosis and is relatively common. Surgery followed by RAI treatment remains the mainstream treatment for a large majority of patients with high- and intermediate-risk DTC, but its benefits should be carefully weighed against the potential for harm. The aim of this paper is to critically review the experience in treating advanced DTC at two tertiary referral centers in Italy.

Methods: Retrospective analysis of 300 patients who underwent surgery for ADTC over 30 years.

Results: The complication rate was 50.33%. A total of 135 patients (45%) remained at regular follow-up, 118 (87.4%) were alive, while 17 (12.6%) were deceased. The mean overall survival at 12 years was 84.8% with a mean of 238 months. Eleven patients (8.1%) experienced a relapse after a median of 13 months.

Conclusions: ADTC patients adequately treated can achieve prolonged survival even in the case of metastasis or disease relapse. Patients with ADTC should be referred to high-volume centers with the availability of an extended multidisciplinary team to receive tailored treatment.

Keywords: cancer; thyroid surgery; treatment.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
overall survival of 135 patients at regular follow-up.
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