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Review
. 2024 Jan 30;13(3):793.
doi: 10.3390/jcm13030793.

Diabetic Kidney Disease in Post-Kidney Transplant Patients

Ngoc-Yen T Pham  1 , Diego Cruz  2 , Luis Madera-Marin  1 , Raja Ravender  1 , Pablo Garcia  1
Affiliations
Review

Diabetic Kidney Disease in Post-Kidney Transplant Patients

Ngoc-Yen T Pham et al. J Clin Med. .

Abstract

Post-transplant diabetes mellitus (PTDM) is a common occurrence in post-kidney transplantation and is associated with greater mortality, allograft failure, and increased risk of infections. The primary goal in the management of PTDM is to achieve glycemic control to minimize the risk of complications while balancing the need for immunosuppression to maintain the health of the transplanted kidney. This review summarizes the effects of maintenance immunosuppression and therapeutic options among kidney transplant recipients. Patients with PTDM are at increased risk of diabetic kidney disease development; therefore, in this review, we focus on evidence supporting the use of novel antidiabetic agents and discuss their benefits and potential side effects in detail.

Keywords: PTDM; diabetes; diabetic nephropathy; kidney transplant.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The pillars of PTDM care. Lifestyle modification must be implemented even prior to transplantation; insulin therapy in the early post-transplant period, GLP-1 agonist could be initiated in the outpatient setting early post-transplant and SGLT-2 inhibitors once a baseline creatinine has been established and there are no concerns for urinary tract infections.
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