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. 2024 Jan 30;13(3):794.
doi: 10.3390/jcm13030794.

Predictive Role of Pre-Operative Anemia in Early Recurrence of Endometrial Cancer: A Single-Center Study in Romania

Mihaela Ionică  1   2 , Marius Biris  3 , Florin Gorun  4 , Nicoleta Nicolae  3 , Zoran Laurentiu Popa  3 , Maria Cezara Muresan  3 , Marius Forga  3 , Dragos Erdelean  3 , Izabella Erdelean  3 , Mihai Adrian Gorun  5 , Octavian Constantin Neagoe  1   2
Affiliations

Predictive Role of Pre-Operative Anemia in Early Recurrence of Endometrial Cancer: A Single-Center Study in Romania

Mihaela Ionică et al. J Clin Med. .

Abstract

This study aims to investigate the association between anemia and early recurrence in endometrial cancer patients. We retrospectively analyzed the data of 473 endometrial cancer patients treated at our hospital from January 2015 to December 2020. Patients were divided into two groups based on their hemoglobin (Hb) level: anemia group (Hb < 12 g/dL) and non-anemia group (Hb ≥12 g/dL). Early recurrence was defined as recurrence within 2 years of diagnosis. Univariate and multivariate logistic regression analyses were used to identify the predictors of early recurrence. The prevalence of anemia was 38.26% (181/473). The incidence of early recurrence was 12.89% (61/473) in the anemia group and 9.24% (38/412) in the non-anemia group (p = 0.004). Univariate analysis showed that anemia was a significant predictor of early recurrence (odds ratio (OR) = 2.27, 95% confidence interval (CI): 1.35-3.80, p = 0.003). Multivariate analysis confirmed that anemia was an independent predictor of early recurrence (OR = 2.11, 95% CI: 1.21-3.84, p = 0.01). Anemia is an independent predictor of early recurrence in endometrial cancer patients. Patients with endometrial cancer should be screened for anemia and treated if present. Additionally, patients with anemia should be closely monitored for early signs of recurrence and treated aggressively.

Keywords: anemia; endometrial cancer; oncologic surgery.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Kaplan-Meier curve of overall survival in endometrial cancer patients by anemia status.
Figure 2
Figure 2
Cox regression survival curve comparing pre-surgery anemia with those who are not anemic.
Figure 3
Figure 3
Correlation between Hb count (g/dL) and time in months to endometrial cancer recurrence.
Figure 4
Figure 4
Kaplan-Meier curve of overall time until recurrence by pre-surgery anemia status.
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