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Review
. 2024 Jan 31;16(3):416.
doi: 10.3390/nu16030416.

Rickets Types and Treatment with Vitamin D and Analogues

Giacomo Biasucci  1   2 , Valentina Donini  3 , Giuseppe Cannalire  1
Affiliations
Review

Rickets Types and Treatment with Vitamin D and Analogues

Giacomo Biasucci et al. Nutrients. .

Abstract

The definition of "Vitamin D" encompasses a group of fat-soluble steroid compounds of different origins with similar chemical structures and the same biological effects. Vitamin D deficiency and/or a defect in the process of its synthesis or transport predispose individuals to several types of rickets. In addition to cholecalciferol, ergocalciferol, and vitamins D3 and D2, there are also active metabolites for the treatment of this condition which are commercially available. Calcitriol and aphacalcidiol are active metabolites that do not require the renal activation step, which is required with calcifediol, or hepatic activation. The purpose of this review is to summarize current approaches to the treatment of rickets for generalist physicians, focusing on the best vitamin D form to be used in each type, or, in the case of X-linked hypophosphatemic rickets (XLH), on both conventional and innovative monoclonal antibody treatments.

Keywords: Burosumab; FGF23; cholecalciferol; ergocalciferol; rickets.

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Conflict of interest statement

The author declares no conflicts of interest.

Figures

Figure 1
Figure 1
Vitamin D metabolism (a) and related genetic disorders (b), modified from [4].
See this image and copyright information in PMC

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