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. 2024 Feb 5;25(3):1900.
doi: 10.3390/ijms25031900.

Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study

Marlene Fabiola Escobedo-Monge  1 , Marianela Marcos-Temprano  2 , Joaquín Parodi-Román  3 , María Antonieta Escobedo-Monge  4 , Carmen Alonso-Vicente  5 , María Carmen Torres-Hinojal  1 , José Manuel Marugán-Miguelsanz  5
Affiliations

Calcium, Phosphorus, and Vitamin D Levels in a Series of Cystic Fibrosis Patients: A Cross-Sectional Study

Marlene Fabiola Escobedo-Monge et al. Int J Mol Sci. .

Abstract

Cystic fibrosis (CF) is a monogenic disease with different types of mutations that mainly affect the respiratory-digestive system. Calcium (Ca), phosphorus (P), and vitamin D (Vit-D) are essential nutrients for maintaining adequate growth and development, as well as key components in crucial metabolic pathways. Proper diagnosis, treatment, and response are decisive components of precision medicine. Therefore, we conducted a cross-sectional study to evaluate Ca, P, and Vit-D levels along with health and nutritional indicators, regarding their non-skeletal functions, in a series of CF patients. Anthropometric and clinical evaluation, biochemical analysis, dietary survey, and respiratory and pancreatic status were performed. Even though the results showed that all patients had normal dietary and serum Ca levels, 47% of patients had deficient Vit-D intake, 53% of patients had hypovitaminosis D, 35% had insufficient Vit-D levels, 18% had hypophosphatemia, 76% had elevated alkaline phosphate levels, 29% had hypercalciuria, and 65% had hyperphosphaturia. There were no significant differences between homozygous and compound heterozygous patients. Ca, P, and Vit-D levels were associated with body mass index; body composition; physical activity; diet; growth hormones; and the immune, liver, and kidney systems. We suggest a periodically evaluation of Ca and P losses.

Keywords: calcium/phosphorus ratio; nutritional status; phosphatase alkaline; physical activity.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Regression urine calcium/phosphate ratio by serum calcium/phosphate ratio.
Figure 2
Figure 2
Regression serum phosphate and tubular maximum phosphate reabsorption per glomerular filtration rate (TmP/GFR mg/dL) by age in years.
Figure 3
Figure 3
Flowchart of a cross-sectional study design to evaluate calcium, phosphorus, and vitamin D status in a series of cystic fibrosis patients (n = 17).
See this image and copyright information in PMC

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References

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