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. 2024 Jun 1;154(11):1911-1919.
doi: 10.1002/ijc.34877. Epub 2024 Feb 10.

Ovarian cancer survival in sub-Saharan Africa by human development index and histological subtypes: A population-based registry study

Muluken Gizaw  1   2   3 , Donald Maxwell Parkin  4   5 , Ole Stöter  2   6 , Phiona Bukirwa  7 , Edom Seife  8 , Gladys Chesumbai  9 , Anne Korir  10 , Biying Liu  5 , Shyam S Manraj  11 , Guy Nda  12 , Nontuthuzelo I M Somdyala  13 , Eva Johanna Kantelhardt  2   6
Affiliations

Ovarian cancer survival in sub-Saharan Africa by human development index and histological subtypes: A population-based registry study

Muluken Gizaw et al. Int J Cancer. .

Abstract

Ovarian cancer (OC) is the fourth most common cancer of women in sub-Saharan Africa (SSA), although few data have been published on population-level survival. We estimate ovarian cancer survival in SSA by human development index and histological subtype, using data from seven population-based cancer registries in six countries: Kenya (Nairobi and Eldoret), Mauritius, Uganda (Kampala), Cote d'Ivoire (Abidjan), Ethiopia (Addis Ababa) and South Africa (Eastern Cape). A total of 644 cases diagnosed during 2008-2014 were included, with 77% being of epithelial subtypes (range 47% [Abidjan]-80% [Mauritius]). The overall observed survival in the study cohort was 73.4% (95% CI: 69.8, 77.0) at 1 year, 54.4% (95% CI: 50.4, 58.7) at 3 years and 45.0% (95% CI: 41.0, 49.4) at 5 years. Relative survival at Year 1 ranged from 44.4% in Kampala to 86.3% in Mauritius, with a mean for the seven series of 67.4%. Relative survival was highest in Mauritius at 72.2% and lowest in Kampala, Uganda at 19.5%, with a mean of 47.8%. There was no difference in survival by age at diagnosis. Patients from high and medium HDI countries had significantly better survival than those from low HDI countries. Women with cancers of epithelial cell origin had much lower survival compared to women with other histological subtypes (p = .02). Adjusted for the young age of the African patients with ovarian cancer (44% aged <50) survival is much lower than in USA or Europe, and underlines the need for improvements in the access to diagnosis and treatment of OC in SSA.

Keywords: HDI; epithelial; ovarian cancer; sub‐Saharan Africa; survival.

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References

REFERENCES

    1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209‐249.
    1. Cabasag CJ, Fagan PJ, Ferlay J, et al. Ovarian cancer today and tomorrow: a global assessment by world region and human development index using GLOBOCAN 2020. Int J Cancer. 2022;151(9):1535‐1541.
    1. Ngwa W, Addai BW, Adewole I, et al. Cancer in sub‐Saharan Africa: a lancet oncology commission. Lancet Oncol. 2022;23(6):e251‐e312.
    1. Bray F, Parkin DM. Cancer in sub‐Saharan Africa in 2020: a review of current estimates of the national burden, data gaps, and future needs. Lancet Oncol. 2022;23(6):719‐728.
    1. Soerjomataram I, Cabasag C, Bardot A, et al. Cancer survival in Africa, central and south America, and Asia (SURVCAN‐3): a population‐based benchmarking study in 32 countries. Lancet Oncol. 2023;24(1):22‐32.