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Comment
. 2024 Feb 10;147(1):34.
doi: 10.1007/s00401-024-02684-3.

Pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion. Scientific commentary on 'Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics'

Alexandre Vasiljevic  1   2
Affiliations
Comment

Pineal parenchymal tumors of intermediate differentiation: in need of a stringent definition to avoid confusion. Scientific commentary on 'Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics'

Alexandre Vasiljevic. Acta Neuropathol. .
No abstract available

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Figures

Fig. 1
Fig. 1
Differences between PPTID-C and KBTBD4-mutated PPTID: The pineal tumor depicted in pictures a to d shows features consistent with the diagnosis of pineal parenchymal tumor of intermediate differentiation (PPTID)-C. In contrast to KBTBD4-mutated PPTID (e, Hematoxylin, Phloxine, Saffron (HPS) staining, × 100), this tumor shows rare foci of pineocytomatous pseudorosettes (transitional architecture) (a, HPS × 100 and insert, HPS × 600). Molecularly, PPTID-C is KBTBD4-wild type and shows 13q loss. Its methylation profile matches with pineocytoma (score = 0.99 in v12.5 of the Heildelberg classifier; www.molecularneuropathology.org). Compared with KBTBD4-mutated PPTID (e–h), PPTID-C (a–d) are composed of larger cells (b > f, HPS × 600) and show higher Neurofilament Protein immunopositivity (c > g, HPS × 200). The Ki67 hotspot proliferation index is here in the range of Rahmanzade’s report (d = 6.3% and h = 8.3%) with no significant difference
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