Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Oct;13(5):493-514.
doi: 10.1007/BF01059332.

The in vitro development of extended-release solid oral dosage forms

L J Leeson, D Adair, J Clevenger, N Chiang

The in vitro development of extended-release solid oral dosage forms

L J Leeson et al. J Pharmacokinet Biopharm. 1985 Oct.

Abstract

A system is described for developing extended-release products, based upon predicting or simulating the entire plasma level-time curve to be expected from the administration of a controlled-release oral dosage form. Termed "biorelevant dissolution," it employs the product's in vitro dissolution behavior and the drug's pharmacokinetic parameters in conjunction with a classical pharmacokinetic model. The basic system is described along with some pertinent examples.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Pharm Sci. 1976 Apr;65(4):601-3 - PubMed
    1. J Pharm Sci. 1971 Apr;60(4):561-4 - PubMed
    1. J Pharm Sci. 1971 Jun;60(6):878-82 - PubMed
    1. J Pharm Pharmacol. 1972 Dec;24(12):979-81 - PubMed
    1. J Pharm Sci. 1970 Dec;59(12):1792-6 - PubMed

LinkOut - more resources