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. 1985 Oct;13(5):493-514.
doi: 10.1007/BF01059332.

The in vitro development of extended-release solid oral dosage forms

L J Leeson, D Adair, J Clevenger, N Chiang

The in vitro development of extended-release solid oral dosage forms

L J Leeson et al. J Pharmacokinet Biopharm. 1985 Oct.

Abstract

A system is described for developing extended-release products, based upon predicting or simulating the entire plasma level-time curve to be expected from the administration of a controlled-release oral dosage form. Termed "biorelevant dissolution," it employs the product's in vitro dissolution behavior and the drug's pharmacokinetic parameters in conjunction with a classical pharmacokinetic model. The basic system is described along with some pertinent examples.

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