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. 2024 Feb 12;36(1):5.
doi: 10.1186/s43046-024-00209-3.

Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia

Salah Aref  1 , Omnyia Khaled  2 , Nadia El Menshawy  2 , Emad Azmy  3 , Mohamed Aref  4 , Osama Salama  2 , Nada Khaled  2
Affiliations

Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia

Salah Aref et al. J Egypt Natl Canc Inst. .

Abstract

Objective: This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients' outcomes.

Methods: SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls.

Results: Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P = < 0.001, P = 0.005 respectively) and AML patients (P < 0.001, P = 0.003 respectively) as compared to control, and decline at complete remission (CR) and elevated again at relapse. High SOX2 and OCT3/4 levels were significantly correlated with the presence of adverse risk stratification parameters.

Conclusion: Our findings indicated that both SOX2 and OCT3/4 could serve as biomarkers that could improve risk stratification of acute leukemia patients. Also, both SOX2 and OCT3/4 might be a therapeutic target, especially in resistant acute leukemia.

Keywords: ALL; AML; OCT3/4; Outcome; SOX2.

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