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. 2024 Feb 12;36(1):5.
doi: 10.1186/s43046-024-00209-3.

Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia

Salah Aref  1 , Omnyia Khaled  2 , Nadia El Menshawy  2 , Emad Azmy  3 , Mohamed Aref  4 , Osama Salama  2 , Nada Khaled  2
Affiliations

Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia

Salah Aref et al. J Egypt Natl Canc Inst. .

Abstract

Objective: This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients' outcomes.

Methods: SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls.

Results: Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P = < 0.001, P = 0.005 respectively) and AML patients (P < 0.001, P = 0.003 respectively) as compared to control, and decline at complete remission (CR) and elevated again at relapse. High SOX2 and OCT3/4 levels were significantly correlated with the presence of adverse risk stratification parameters.

Conclusion: Our findings indicated that both SOX2 and OCT3/4 could serve as biomarkers that could improve risk stratification of acute leukemia patients. Also, both SOX2 and OCT3/4 might be a therapeutic target, especially in resistant acute leukemia.

Keywords: ALL; AML; OCT3/4; Outcome; SOX2.

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References

    1. Sas, V., Moisoiu, V., Teodorescu, P., et al. Approach to the adult acute lymphoblastic leukemia patient. J Clin Med.2019; 8(8). https://doi.org/10.3390/jcm8081175 .
    1. Siegel, Rebecca L., Miller, Kimberly D., Fuchs, Hannah E., et al. Cancer statistics, 2022. CA Cancer J Clin. 72(1), 7-33. https://doi.org/10.3322/caac.21708 .
    1. National Cancer Institute. Cancer stat facts: leukemia-acute myeloid leukemia. U.S. Department of Health and Human Services, National Institutes of Health. 2021; https://seer.cancer.gov/statfacts/html/amyl.html.
    1. Howlader N, Noone AM, Krapcho M, et al (eds). SEER Cancer Statistics Review, 1975-2014, National Cancer Institute. Bethesda, MD, https://seer.cancer.gov/csr/1975_2014/ , based on November 2016 SEER data submission, posted to the SEER web site, April 2017.
    1. Malard Florent. Mohty, Mohamad. Acute lymphoblastic leukaemia. Lancet. 2020;395(10230):1146–62. https://doi.org/10.1016/S0140-6736(19)33018-1 . - DOI - PubMed

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