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. 2024 Mar;44(3):289-296.
doi: 10.1002/pd.6533. Epub 2024 Feb 11.

The role of confined placental mosaicism in fetal growth restriction: A retrospective cohort study

Geerke M Eggenhuizen  1 , Attie T J I Go  1 , Zoë Sauter  1 , Mariëtte J V Hoffer  2 , Monique C Haak  3 , Geert Geeven  4 , Karin E M Diderich  4 , Marieke Joosten  4 , Myrthe van den Born  4 , Malgorzata I Srebniak  4 , Diane Van Opstal  4
Affiliations

The role of confined placental mosaicism in fetal growth restriction: A retrospective cohort study

Geerke M Eggenhuizen et al. Prenat Diagn. 2024 Mar.

Abstract

Objective: To evaluate which cytogenetic characteristics of confined placental mosaicism (CPM) detected in the first trimester chorionic villi and/or placentas in terms of chromosome aberration, cell lineage involved and trisomy origin will lead to fetal growth restriction and low birthweight.

Methods: Cohort study using routinely collected perinatal data and cytogenetic data of non-invasive prenatal testing, the first trimester chorionic villi sampling and postnatal placentas.

Results: 215 CPM cases were found. Fetal growth restriction (FGR) and low birthweight below the 10th percentile (BW < p10) were seen in 34.0% and 23.1%, respectively. Excluding cases of trisomy 16, 29.1% showed FGR and 17.9% had a BW < p10. The highest rate of FGR and BW < p10 was found in CPM type 3, but differences with type 1 and 2 were not significant. FGR and BW < p10 were significantly more often observed in cases with meiotic trisomies.

Conclusion: There is an association between CPM and FGR and BW < p10. This association is not restricted to trisomy 16, neither to CPM type 3, nor to CPM involving a meiotic trisomy. Pregnancies with all CPM types and origins should be considered to be at increased risk of FGR and low BW < p10. A close prenatal fetal monitoring is indicated in all cases of CPM.

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References

REFERENCES

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