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Review
. 2024 Jan 26:11:1305638.
doi: 10.3389/fmed.2024.1305638. eCollection 2024.

Exploring the association between asthma and chronic comorbidities: impact on clinical outcomes

Aditya Sri Listyoko  1   2 , Ryota Okazaki  1 , Tomoya Harada  1 , Genki Inui  1 , Akira Yamasaki  1
Affiliations
Review

Exploring the association between asthma and chronic comorbidities: impact on clinical outcomes

Aditya Sri Listyoko et al. Front Med (Lausanne). .

Abstract

Asthma remains a significant global health challenge. While both the incidence and mortality rates have shown a decline, older individuals with asthma exhibit not just more severe symptoms but also demonstrate an elevated mortality rate. This phenomenon could be attributed to the presence of chronic comorbidities that exert an influence on clinical outcomes among adult patients with asthma. This review aims to present various aspects of asthma comprehensively, including the prevalence, incidence, mortality rates, and causes of death in adult patients with asthma. Additionally, this review delves into the impact of chronic comorbidities that contribute to the morbidity and mortality of patients with asthma on a global scale, encompassing conditions such as chronic kidney disease, diabetes mellitus, lung cancer, obesity, and cardiovascular disease, concerning asthma. Furthermore, the manuscript reviews the distinctions between asthma and asthma chronic obstructive pulmonary disease overlap and adds perspective on asthma as an occupational lung disease. Thus, this review aims to enhance clinicians' awareness of the significance of chronic comorbidities in the management of patients with asthma. It seeks to provide insights that contribute to a more comprehensive approach to managing patients with asthma who also have comorbid conditions.

Keywords: ACO; asthma; comorbidity; mortality; outcomes.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Asthma-related comorbidities have been reported in guidelines or literature.
Figure 2
Figure 2
Comparison between asthma, COPD, and ACO. Abbreviation: post-BD: post-bronchodilator; FEV1, forced expiratory volume in 1 s; RV, residual volume; FRC, functional residual capacity; TLC, total lung capacity; DLCO, diffusing capacity for carbon monoxide; BGA, blood gas analysis; FeNO, fractional exhaled nitric oxide; AHR, airway hyperresponsiveness; FVC, forced vital capacity; LLN, lower limit normal; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio.
See this image and copyright information in PMC

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