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. 2023 Dec 22;11(2):ofad658.
doi: 10.1093/ofid/ofad658. eCollection 2024 Feb.

Cryptococcus neoformans Infections Differ Among Human Immunodeficiency Virus (HIV)-Seropositive and HIV-Seronegative Individuals: Results From a Nationwide Surveillance Program in France

Olivier Paccoud  1 , Marie Desnos-Ollivier  2 , Sophie Cassaing  3 , Karine Boukris-Sitbon  2 , Alexandre Alanio  2   4 , Anne-Pauline Bellanger  5 , Christine Bonnal  6 , Julie Bonhomme  7 , Françoise Botterel  8 , Marie-Elisabeth Bougnoux  9   10 , Sophie Brun  11 , Taieb Chouaki  12   13 , Muriel Cornet  14 , Eric Dannaoui  2   9 , Magalie Demar  15 , Nicole Desbois-Nogard  16 , Marie-Fleur Durieux  17 , Loïc Favennec  18   19 , Arnaud Fekkar  20   21 , Frederic Gabriel  22 , Jean-Pierre Gangneux  23   24 , Juliette Guitard  25 , Lilia Hasseine  26 , Antoine Huguenin  27 , Solène Le Gal  28 , Valérie Letscher-Bru  29 , Caroline Mahinc  30 , Florent Morio  31 , Muriel Nicolas  32 , Célia Rouges  33 , Estelle Cateau  34 , Florence Persat  35   36 , Philippe Poirier  37 , Stéphane Ranque  38 , Gabrielle Roosen  39 , Anne-Laure Roux  40   41 , Milène Sasso  42 , Olivier Lortholary  1   2 , Fanny Lanternier  1   2 ; French Mycoses Study Group
Collaborators, Affiliations

Cryptococcus neoformans Infections Differ Among Human Immunodeficiency Virus (HIV)-Seropositive and HIV-Seronegative Individuals: Results From a Nationwide Surveillance Program in France

Olivier Paccoud et al. Open Forum Infect Dis. .

Abstract

Among 1107 cryptococcosis cases from the French surveillance network (2005-2020), the proportion of HIV-seronegative individuals has recently surpassed that of HIV-seropositive individuals. We observed marked differences in patient characteristics, disease presentations, cryptococcal antigen results, infecting species, and mortality according to HIV serostatus.

Keywords: cryptococcal meningitis; cryptococcosis; fungemia; human immunodeficiency virus.

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Conflict of interest statement

Potential conflicts of interest. Over the past 5 years, E. D. has received research grants from MSD, Gilead, and bioMérieux; travel grants from Gilead, MSD, and Pfizer; and speaker's fees from Gilead and Pfizer. All other authors report no potential conflicts of interest.

Figures

Graphical Abstract
Graphical Abstract
Figure 1.
Figure 1.
Number of cases reported to the NRCMA over time according to underlying HIV status, France.
See this image and copyright information in PMC

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