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Case Reports
. 2024 Jan;97(1):95-98.
doi: 10.15386/mpr-2541. Epub 2024 Jan 29.

Acute onset of Lambert Eaton myasthenic syndrome in prostate adenocarcinoma: a case report

Nicu Cătălin Drăghici  1   2   3 , Elena Olariu  4 , Tudor Dimitrie Lupescu  1   3 , Fior Dafin Mureşanu  1   3
Affiliations
Case Reports

Acute onset of Lambert Eaton myasthenic syndrome in prostate adenocarcinoma: a case report

Nicu Cătălin Drăghici et al. Med Pharm Rep. 2024 Jan.

Abstract

Lambert Eaton myasthenic syndrome (LEMS) is a rare disorder of the neuromuscular junction. The representative clinical triad consists of proximal muscular weakness, areflexia and autonomic dysfunction. The diagnosis is based on the clinical findings confirmed by voltage-gated calcium channels antibody titer and neurophysiology. We present a 69 year old male with prostate adenocarcinoma and 30 years history of smoking, referred for muscle weakness in the lower limbs and difficulty to climb the stairs.

Keywords: Lambert Eaton myasthenic syndrome; neurophysiology; voltage-gated calcium channels.

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Figures

Figure 1
Figure 1
Bilateral ptosis and generally diminished muscle strength.
Figure 2
Figure 2
Increasing of the amplitude and area of abductor pollicis brevis CMAP (Compound Muscle Action Potential) after 10 seconds of contraction.
Figure 3
Figure 3
(A) Axial, (B) coronal and (C) sagittal contrast-enhanced computed tomography (CT) images of the chest.
See this image and copyright information in PMC

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