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Review
. 2024;24(12):1187-1194.
doi: 10.2174/0115680096281059240103154836.

The Role of Local Angiotensin II/Angiotensin Type 1-receptor Mechanisms in Adipose Tissue Dysfunction to Promote Pancreatic Cancer

Rozita Khodashahi  1   2 , Fatemeh Beiraghdar  3 , Gorgon A Ferns  4 , Kiayash Ashrafzadeh  1 , Mohsen Aliakbarian  1   5 , Mohammad-Hassan Arjmand  1
Affiliations
Review

The Role of Local Angiotensin II/Angiotensin Type 1-receptor Mechanisms in Adipose Tissue Dysfunction to Promote Pancreatic Cancer

Rozita Khodashahi et al. Curr Cancer Drug Targets. 2024.

Abstract

Obesity and adipose tissue dysfunction are important risk factors for pancreatic cancer. Pancreatic cancer is one of the most lethal cancers globally. The renin-angiotensin system (RAS) is expressed in many tissues, including adipose tissue. Dysregulation of angiotensin II and angiotensin II receptors in adipose tissue through the activation of different signaling pathways leads to adipose tissue dysfunction, including insulin resistance, adipose tissue inflammation, adipocytokines secretion, and metabolic alterations. The pathogenesis of pancreatic cancer remains uncertain. However, there is evidence that dysregulation of local angiotensin II in adipose tissue that occurs in association with obesity is, in part, responsible for the initiation and progression of pancreatic cancer. Due to the role of local angiotensin II in the dysfunction of adipose tissue, angiotensin receptor blockers may be considered a new therapeutic strategy in the amelioration of the complications related to adipose tissue dysfunction and prevention of pancreatic cancer. This review aims to consider the biological roles of local angiotensin II and angiotensin II receptors in adipose tissue dysfunction to promote pancreatic cancer progression with a focus on adipose tissue inflammation and metabolic reprogramming.

Keywords: Adipose tissue; angiotensin II; angiotensin receptor; angiotensin receptor.; obesity; pancreatic cancer.

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References

    1. Martyniak A.; Tomasik P.J.; A new perspective on the renin-angiotensin system. Diagnostics 2022,13(1),16 - DOI - PubMed
    1. Kanugula A.K.; Kaur J.; Batra J.; Ankireddypalli A.R.; Velagapudi R.; Renin-angiotensin system: Updated understanding and role in physiological and pathophysiological states. Cureus 2023,15(6),e40725 - DOI - PubMed
    1. El Sebaey R.S.; Assessment of possible role of renin angiotensin aldosterone system in obesity. Egypt J Hosp Med 2023,91(1),4828-4831 - DOI
    1. Iwai M.; Horiuchi M.; Role of renin-angiotensin system in adipose tissue dysfunction. Hypertens Res 2009,32(6),425-427 - DOI - PubMed
    1. Pahlavani M.; Kalupahana N.S.; Ramalingam L.; Moustaid-Moussa N.; Regulation and functions of the renin-angiotensin system in white and brown adipose tissue. Compr Physiol 2017,7(4),1137-1150 - DOI - PubMed

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