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Review
. 2024 Jan 29:15:1356268.
doi: 10.3389/fimmu.2024.1356268. eCollection 2024.

Case report: A novel perspective on the treatment of primary tracheal small cell carcinoma: a patient's experience with immuno-combined EP therapy and literature review

Yu Chen  1 , Hongbin Zhu  1 , Danping Wang  1 , Yalan Ye  1 , Jianrong Gao  1
Affiliations
Review

Case report: A novel perspective on the treatment of primary tracheal small cell carcinoma: a patient's experience with immuno-combined EP therapy and literature review

Yu Chen et al. Front Immunol. .

Abstract

Tracheal small cell carcinoma (SCC) is a rare malignancy, for which the optimal treatment strategy has yet to be determined. Currently, treatment largely aligns with the therapeutic guidelines established for small cell lung cancer, although numerous unresolved issues remain. This paper details a case study of a patient with Stage IIIB primary tracheal SCC, who was treated with an immune-combined etoposide-platinum(EP) regimen. This treatment offers valuable insights into innovative approaches for managing such malignancies. Furthermore, the study includes a comprehensive literature review to better contextualize the findings. The patient, admitted on May 2, 2023, had been experiencing persistent symptoms of airway discomfort for 15 days. A bronchoscopy performed on May 4 revealed tracheal SCC, classified as T4N2M0, IIIB. Following the CAPSTONE-1 study's methodology, the patient underwent six cycles of PD-L1(adebrelimab) combined with EP therapy, leading to significant relief of symptoms and the eventual disappearance of the tracheal mass.

Keywords: adebrelimab; etoposide-platinum regimen; immune-combined therapy; optimal treatment strategy; tracheal small cell carcinoma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) 2023-5-2 Pulmonary CT Findings: Tracheal Prominence Occupancy. (B) 2023-6-28Pulmonary CT Findings: Significant Reduction in the Mass Below the Tracheal Prominence. (C, D) 2023-8-22 and 2023-11-1Pulmonary CT Findings: Absence of Mass Below the Tracheal Prominence in Both. The red arrows are used to indicate the location of tumor.
Figure 2
Figure 2
(A) 2023-5-5 Fibrobronchoscopy Reveals: Compression of the Tracheal Glottis, Narrowing of the Lumen, and Mucosal Swelling and Congestion. (B) 2023-11-2 Fibrobronchoscopy Reveals: The Tracheal Eminence Mass Has Disappeared, Localized with Slight Nodular Protrusions. The red arrows are used to indicate the location of tumor.
Figure 3
Figure 3
2023-5-5 Pathological Images: Image (A) Displays Tumor Tissue Cells Under 400x Magnification, Image (B) Presents Cells of Para-cancerous Tissue Under 400x Magnification.
See this image and copyright information in PMC

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