Recent Advances in Palladium-Catalyzed Asymmetric Heck/Tsuji-Trost Reactions of 1,n-Dienes

Guofeng Zhao^{1

2}, Wenbo Li², Junliang Zhang^{2

3}

Affiliations

¹ School of Chemistry and Chemical Engineering, Henan University of Science and Technology, Luoyang, 471023, China.
² Shanghai Key Laboratory of Green Chemistry and Chemical Processes, State Key Laboratory of Petroleum Molecular & Process Engineering, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, P. R. China.
³ Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, P. R. China.

PMID: 38349344
DOI: 10.1002/chem.202400076

Review

Recent Advances in Palladium-Catalyzed Asymmetric Heck/Tsuji-Trost Reactions of 1,n-Dienes

Guofeng Zhao et al. Chemistry. 2024.

. 2024 May 8;30(26):e202400076.

doi: 10.1002/chem.202400076. Epub 2024 Feb 29.

Authors

Guofeng Zhao^{1

2}, Wenbo Li², Junliang Zhang^{2

3}

Affiliations

¹ School of Chemistry and Chemical Engineering, Henan University of Science and Technology, Luoyang, 471023, China.
² Shanghai Key Laboratory of Green Chemistry and Chemical Processes, State Key Laboratory of Petroleum Molecular & Process Engineering, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, P. R. China.
³ Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, P. R. China.

PMID: 38349344
DOI: 10.1002/chem.202400076

Abstract

Transition-metal catalyzed tandem asymmetric reactions were powerful tools to access various chiral compounds. Many strategies have been developed for the coupling of 1,n-dienes with aryl halides via a tandem Heck/Tsuji-Trost process. However, the control of regio- and stereo-chemistry remains a challenging task. This minireview details the recent advances in the field of asymmetric Heck/Tsuji-Trost reactions catalyzed by palladium complex, which have opened new opportunities and expanded our understanding in this area of research in recent years.

Keywords: 1,n-Dienes; Asymmetric catalysis; Difunctionalization; Heck/Tsuji–Trost; Palladium.

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References

1. None
1. R. F. Heck, J. P. Nolley Jr., J. Org. Chem. 1972, 37, 2320–2322;
1. J. Muzart, Tetrahedron 2007, 63, 7505–7521.
1. None
1. X. Zhang, A. Liu, W. Chen, Org. Lett. 2008, 10, 3849–3852;

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Recent Advances in Palladium-Catalyzed Asymmetric Heck/Tsuji-Trost Reactions of 1,n-Dienes

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Recent Advances in Palladium-Catalyzed Asymmetric Heck/Tsuji-Trost Reactions of 1,n-Dienes

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