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Review
. 2024 May;60(5):502-512.
doi: 10.1007/s11626-024-00860-z. Epub 2024 Feb 13.

The interplay between Wnt signaling pathways and microtubule dynamics

Koji Kikuchi  1 , Masaki Arata  2
Affiliations
Review

The interplay between Wnt signaling pathways and microtubule dynamics

Koji Kikuchi et al. In Vitro Cell Dev Biol Anim. 2024 May.

Erratum in

Abstract

Wnt signaling pathways represent an evolutionarily highly conserved, intricate network of molecular interactions that regulates various aspects of cellular behavior, including embryonic development and tissue homeostasis. Wnt signaling pathways share the β-catenin-dependent (canonical) and the multiple β-catenin-independent (non-canonical) pathways. These pathways collectively orchestrate a wide range of cellular processes through distinct mechanisms of action. Both the β-catenin-dependent and β-catenin-independent pathways are closely intertwined with microtubule dynamics, underscoring the complex crosstalk between Wnt signaling and the cellular cytoskeleton. This interplay involves several mechanisms, including how the components of Wnt signaling can influence the stability, organization, and distribution of microtubules. The modulation of microtubule dynamics by Wnt signaling plays a crucial role in coordinating cellular behaviors and responses to external signals. In this comprehensive review, we discussed the current understanding of how Wnt signaling and microtubule dynamics intersect in various aspects of cellular behavior. This study provides insights into our understanding of these crucial cellular processes.

Keywords: Microtubule dynamics; Wnt signaling; β-Catenin-dependent pathway; β-Catenin-independent pathway.

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