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. 2024 Feb 13;19(6):807-809.
doi: 10.2215/CJN.0000000000000442. Epub 2024 Feb 13.

Fructokinase Inhibition to Prevent Kidney Disease

Didier Ducloux  1
Affiliations

Fructokinase Inhibition to Prevent Kidney Disease

Didier Ducloux. Clin J Am Soc Nephrol. .
No abstract available

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Conflict of interest statement

The author has nothing to disclose.

Figures

Figure 1
Figure 1
Different mechanisms supporting the effects of fructose on CKD. Different conditions including diabetes, renal hypoxia, high salt intake, and aging activate the polyol pathway. In the proximal tubule, glucose, not used for energy, will enter in the polyol pathway and be transformed in sorbitol that can be converted to fructose, which is then largely metabolized by fructokinase, leading to ATP depletion, proinflammatory cytokine expression, and oxidative stress. AR, aldose reductase; IMP, inosine monophosphate; NO, nitric oxide; ROS, reactive oxygen species; SDH, sorbitol dehydrogenase.
See this image and copyright information in PMC

References

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