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. 2024 Feb:85:101747.
doi: 10.1016/j.biologicals.2024.101747. Epub 2024 Feb 13.

Fourth Controlled Human Infection Model (CHIM) meeting - CHIMs in endemic countries, May 22-23, 2023

Melissa Kapulu  1 , Lucinda Manda-Taylor  2 , Shobana Balasingam  3 , Gary Means  4 , Mikal Ayiro Malungu  5 , Philip Bejon  6 , Primus Che Chi  7 , Christopher Chiu  8 , E Chandler Church  9 , Rodrigo Correa-Oliveira  10 , Nicholas Day  11 , Anna Durbin  12 , Moses Egesa  13 , Claudia Emerson  14 , Kondwani Jambo  15 , Roli Mathur  16 , Wolfram Metzger  17 , Noni Mumba  18 , Winfred Nazziwa  19 , Ally Olotu  20 , Jacqueline Rodgers  21 , Frank Sinyiza  22 , Kawsar Talaat  23 , Ingrid Kamerling  24 , Charlie Weller  25 , Marc Baay  26 , Pieter Neels  27
Affiliations

Fourth Controlled Human Infection Model (CHIM) meeting - CHIMs in endemic countries, May 22-23, 2023

Melissa Kapulu et al. Biologicals. 2024 Feb.

Abstract

Earlier meetings laid the foundations for Controlled Human Infection Models (CHIMs), also known as human challenge studies and human infection studies, including Good Manufacturing Practice (GMP) production of the challenge agent, CHIM ethics, environmental safety in CHIM, recruitment, community engagement, advertising and incentives, pre-existing immunity, and clinical, immunological, and microbiological endpoints. The fourth CHIM meeting focused on CHIM studies being conducted in endemic countries. Over the last ten years we have seen a vast expansion of the number of countries in Africa performing CHIM studies, as well as a growing number of different challenge organisms being used. Community and public engagement with assiduous ethical and regulatory oversight has been central to successful introductions and should be continued, in more community-led or community-driven models. Valuable initiatives for regulation of CHIMs have been undertaken but further capacity building remains essential.

Keywords: Deliberate infection; Endemic diseases; Human challenge; Human infection studies; Infectious diseases; Low- and middle-income countries; Vaccine.

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Conflict of interest statement

Declaration of competing interest All authors declare no competing interests.

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