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Review
. 2024 Feb 13;28(1):45.
doi: 10.1186/s13054-024-04805-6.

Transforming research to improve therapies for trauma in the twenty-first century

Nicole P Juffermans  1   2 , Tarik Gözden  3 , Karim Brohi  4 , Ross Davenport  4 , Jason P Acker  5   6 , Michael C Reade  7   8 , Marc Maegele  9 , Matthew D Neal  10 , Philip C Spinella  10
Affiliations
Review

Transforming research to improve therapies for trauma in the twenty-first century

Nicole P Juffermans et al. Crit Care. .

Abstract

Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. However, as specific treatments for bleeding are largely lacking, many patients continue to die from hemorrhage. Also, major knowledge gaps remain on the impact of tissue injury on the host immune and coagulation response, which hampers the development of interventions to treat or prevent organ failure, thrombosis, infections or other complications of trauma. Thereby, trauma remains a challenge for intensivists. This review describes the most pressing research questions in trauma, as well as new approaches to trauma research, with the aim to bring improved therapies to the bedside within the twenty-first century.

Keywords: Future of care; Research methodology; Therapies; Trauma.

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Conflict of interest statement

Philip C. Spinella: Consultant for Cerus, Hemanext, CSL Behring. Advisory board for Haima and Octapharma. Co-Founder and Chief Medical Office for Kalocyte. Nicole Juffermans: consultant for Octapharma. Advisory board for Bayer.

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Fig. 1
A translational approach to improve therapies for trauma
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