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. 2024 Jun;51(7):1955-1964.
doi: 10.1007/s00259-024-06643-8. Epub 2024 Feb 14.

Prognostic value of baseline and interim [18F]FDG PET metabolic parameters in pediatric Hodgkin's lymphoma

Mikhail Ya Yadgarov  1   2 , M M Dunaykin  3 , G I Shestopalov  3   4 , C Kailash  3 , E D Kireeva  3 , N V Myakova  3 , Yu N Likar  3
Affiliations

Prognostic value of baseline and interim [18F]FDG PET metabolic parameters in pediatric Hodgkin's lymphoma

Mikhail Ya Yadgarov et al. Eur J Nucl Med Mol Imaging. 2024 Jun.

Abstract

Background: Hodgkin lymphoma (HL) in pediatric populations has a high survival rate but poses risks for long-term morbidities. Although [18F]fluoro‑2‑deoxy‑2‑d‑glucose positron emission tomography ([18F]FDG PET) scans offer potential for improved risk stratification, the definitive prognostic value of quantitative [18F]FDG PET parameters remains unclear for pediatric HL.

Methods: A single-center, retrospective study included pediatric patients diagnosed with HL between 2016 and 2023 treated according to EuroNet-PHL-C1 and DAL/GPOH-HD protocols. Patients underwent baseline and interim PET/CT scans after two chemotherapy cycles. Event-free survival (EFS) was the primary endpoint, Deauville score was the secondary endpoint. Quantitative [18F]FDG PET parameters included SUVmax, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) that were evaluated using two segmentation methods (SUV 2.5, 41% SUVmax). Survival outcomes were assessed using Cox regression analysis.

Results: A total of 115 patients (50 males, median age 14.2 years) were studied, with a median follow-up period of 35 months. During this period, 16 cases (13.9%) of relapse or progression were noted. Baseline and interim MTV 2.5, MTV 41%, TLG 2.5, and TLG 41%, along with interim SUVmax, were significantly associated with worse EFS and correlated with post-treatment Deauville scores. In multivariable analysis, interim MTV 2.5 > 0 ml (adj. hazard ratio, HR: 3.89, p = 0.009) and interim TLG 41% ≥ 30 g (adj. HR: 7.98, p = 0.006) were independent risk factors for EFS.

Conclusion: Baseline and interim [18F]FDG PET parameters can serve as significant prognostic indicators for EFS and treatment response in pediatric HL. These quantitative measures could enhance individualized, risk-adapted treatment strategies for children and adolescents with HL.

Keywords: Event-free survival; Metabolic tumor volume; Pediatric Hodgkin Lymphoma; Segmentation; Total lesion glycolysis; [18F]FDG PET.

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References

    1. Kahn JM, Pei Q, Friedman DL, et al. Survival by age in paediatric and adolescent patients with Hodgkin lymphoma: a retrospective pooled analysis of children’s oncology group trials. Lancet Haematol. 2022;9:e49-57. https://doi.org/10.1016/S2352-3026(21)00349-5 . - DOI - PubMed - PMC
    1. Perez-Callejo D, Zurutuza L, Royuela A, et al. Long-term follow up of Hodgkin lymphoma. Oncotarget. 2018;9:11638–45. https://doi.org/10.18632/oncotarget.24392 . - DOI - PubMed - PMC
    1. Kelly KM, Cole PD, Pei Q, et al. Response-adapted therapy for the treatment of children with newly diagnosed high risk Hodgkin lymphoma (AHOD0831): a report from the Children’s Oncology Group. Br J Haematol. 2019;187:39–48. https://doi.org/10.1111/bjh.16014 . - DOI - PubMed - PMC
    1. Van Nimwegen FA, Schaapveld M, Janus CPM, et al. Cardiovascular disease after hodgkin lymphoma treatment 40-year disease risk. JAMA Intern Med. 2015;175:1007–17. https://doi.org/10.1001/jamainternmed.2015.1180 . - DOI - PubMed
    1. Holmqvist AS, Chen Y, Berano Teh J, et al. Risk of solid subsequent malignant neoplasms after childhood Hodgkin lymphoma—Identification of high-risk populations to guide surveillance: A report from the Late Effects Study Group. Cancer. 2019;125:1373–83. https://doi.org/10.1002/cncr.31807 . - DOI - PubMed

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