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. 2023 Oct 31;65(5):707-712.
doi: 10.3897/folmed.65.e101356.

Cell adhesion molecules in the pathogenesis of the schizophrenia

Antonino Messina  1 , Caterina Crescimanno  2 , Giuseppe Cuccì  3 , Filippo Caraci  4 , Maria Salvina Signorelli  5
Affiliations

Cell adhesion molecules in the pathogenesis of the schizophrenia

Antonino Messina et al. Folia Med (Plovdiv). .

Abstract

The causes of schizophrenia remain obscure and complex to identify. Alterations in dopaminergic and serotonergic neurotransmission are, to date, the primary pharmacological targets in treatment. Underlying abnormalities in neural networks have been identified as cell adhesion molecules (CAMs) involved in synaptic remodeling and interplay between neurons-neurons and neurons-glial cells. Among the CAMs, several families have been identified, such as integrins, selectins, cadherins, immunoglobulins, nectins, and the neuroligin-neurexin complex. In this paper, cell adhesion molecules involved in the pathogenesis of schizophrenia will be described.

Keywords: cadherins immunoglobulin integrin nectin neurexin/neuroligins selectin synaptic remodeling.

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